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논문번호 77
논문제목(영문) A novel polymer-free drug-eluting stent coated with everolimus using nitrogen-doped titanium dioxide film deposition in a porcine coronary restenosis model.
국내외구분 국외 SCI여부 SCI(E)
연구책임자역할 교신저자
주저자명 Sim DS
교신저자명 Jeong MH
공동저자명 Sim DS, Jeong MH, Park DS, Kim JH, Lim KS, Bae IH, Zhehao P, Yang HY, Lee JH, Hyun DY, Hong YJ, Kim JH, Ahn Y, Kang JC.
게제년월일 2016-07-30
ISSN 0167-5723
Impact Factor 4.036
학술지명 International Journal of Cardiology
서지사항 0집 / 222권 / 1호,   페이지(436 - 440)
요약초록문
(Abstract) 입력		 Abstract
BACKGROUND:
Titanium dioxide (TiO2) films have superior biocompatibility and may be effective as drug-binding matrices for drug-eluting stents (DESs). We sought to evaluate efficacy of a polymer-free DES coated with everolimus using nitrogen-doped TiO2 film deposition in a porcine coronary restenosis model.
METHODS:
Forty coronary arteries in 20 pigs were randomly allocated to group 1 (bare-metal stents (BMSs), 3.0×18mm, n=10), group 2 (BMSs with nitrogen-doped TiO2 film deposition, 3.0×18mm, n=10), group 3 [commercial everolimus-eluting stent, 3.0×18mm, n=10], and group 4 (polymer-free everolimus-eluting stent using nitrogen-doped TiO2 film deposition, 3.0×18mm, n=10). Stents were randomly implanted in the left anterior descending coronary artery and left circumflex artery with stent:artery ratio of 1.3. Four weeks later, pigs underwent follow-up coronary angiography and were sacrificed for histopathologic analysis.
RESULTS:
Percent area stenosis was greater in group 1 compared to groups 3 and 4 (46.4±13.8% vs. 30.2±11.7% vs. 29.2±8.9%, respectively, p=0.005). Fibrin score was lower in groups 1 and 2, compared to groups 3 and 4: 0.87±0.67 vs. 0.76±0.61 vs. 2.27±0.24 vs. 1.75±0.31, respectively, p<0.001). Injury score and inflammation score were not different. Comparison between DES showed a higher fibrin score in group 3 than group 4 (2.27±0.24 vs. 1.75±0.31, p=0.023).
CONCLUSIONS:
In a porcine model of coronary restenosis, a novel polymer-free DES using nitrogen-doped TiO2 film deposition shows higher biocompatibility and compares favorably with a commercial DES.
파일  B77.+Int+J+Cardiol.+2016;222(1)436-440..pdf (1.6M) DATE : 2021-05-21 11:32:13