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논문번호 78
논문제목(영문) Optimal coating method for a dual-layer stent with sirolimus and alpha-lipoic acid in a porcine coronary restenosis model.
국내외구분 국외 SCI여부 SCI(E)
연구책임자역할 교신저자
주저자명 Kyung Seob Lim, Jun-Kyu Park,
교신저자명 Myung Ho Jeong,
공동저자명 Kyung Seob Lim, Jun-Kyu Park, Myung Ho Jeong, In-Ho Bae, Jae-Woon Nah, Dae Sung Park, Jae-Won Sim, Jung Ha Kim, So Youn Lee, Eun Jae Jang, Suyoung Jang, Hyun Kuk Kim, Doo Sun Sim, In Soo Kim, Young Joon Hong, Youngkeun Ahn, Jung Chaee Kang.
게제년월일 2016-07-01
ISSN 1598-5032
Impact Factor 1.357
학술지명 Macromolecular Research
서지사항 0집 / 24권 / n호,   페이지(725 - 733)
요약초록문
(Abstract) 입력		 The aim of this study was to evaluate the optimal method for coating a double-layer polymer coronary stent with sirolimus and alpha-lipoic acid (ALA) in a porcine coronary overstretch restenosis model. Pigs were randomized into three groups, in which the coronary arteries (10 in each group) were stented with a dual-layer stent with an inner layer of ALA and an outer layer of sirolimus (IAOS, n=10), a dual-layer stent with an inner layer of sirolimus and an outer layer of ALA (ISOA, n=10), or a commercial drug-eluting stent (biolimus-eluting stent, BES, n=10). Histopathological analysis was performed 28 days after stenting. There were no significant differences among the three groups in injury and inflammation scores. There were significant differences among the three groups in neointimal area (1.1±0.16 mm2 for IAOS vs. 1.3±0.41 mm2 for ISOA vs. 1.9±0.50 mm2 for BES, p<0.0001), and percentage of stenosis area (21.4±3.08% for IAOS vs. 29.9±7.72% for ISOA vs. 38.2±9.08% for BES, p<0.0001). Regarding the percentage of stenosis area, microcomputed tomography revealed significant differences between the three groups (23.8±3.51% for IAOS vs. 28.9±4.65% for ISOA vs. 36.4±8.07% for BES, p<0.05). Compared with commercial stent placement, both IAOS and ISOA resulted in significant inhibition of neointimal formation in a porcine coronary restenosis model. In addition, IAOS was more effective than ISOA in preventing anti-neointimal hyperplasia after stenting.
파일  B78.Optimal+coating+method+for+a+dual-layer+stent+with+sirolimus+and+alpha-lipoic+acid+in+a+porcine+coronary+restenosis+model..pdf (2.0M) DATE : 2021-05-21 11:32:48