비임상

HOME > 연구실적 > 비임상 > 논문
 
작성일 : 18-05-28 11:11
논문번호 87
논문제목(영문) Effect of a Non-polymer Titanium Dioxide Thin Film-Coated Stent with Heparin in a Porcine Coronary Restenosis Model
국내외구분 국내 SCI여부 KCI
연구책임자역할 교신저자
주저자명 Lim KS
교신저자명 Jeong MH
공동저자명 Lim KS, Jeong MH, Bae IH, Park JK, Park DS, Shim JW, Kim HB, Jin MR, Kim HK, Kim SS, Kim MC, Sim DS, Hong YJ, Kim JH, Ahn Y
게제년월일 2017-11-10
ISSN 2288-8209
Impact Factor 0
학술지명 Clinical & EXPERIMENTAL THROMBOSIS AND HEMOSTASIS
서지사항 1집 / 3권 / 2호,   페이지(17 - 23)
요약초록문
(Abstract) 입력		 Purpose
The aim of this study was to examine the effect of non-polymer titanium dioxide (TiO2) thin film-coated stents modified with heparin in a porcine coronary overstretch restenosis model.
Methods
Pigs were randomized into three groups in which either TiO2 film-heparin coated stent (THS, n=12), zotarolimus-eluting stent with polymer (ZES, n=12), or bare metal stent (BMS, n=12) was placed in a coronary artery (18 pigs, 12 coronaries in each group). Histopathologic analysis was performed at 28 days after stenting.
Results
There was no significant difference in injury score among the three groups. There were significant differences in neointima area (2.9±0.85 mm2 in the THS group vs. 2.8±0.10 mm2 in the ZES group vs. 3.3±0.58 mm2 in the BMS group, P<0.05), fibrin score (0.0 [range 0.0 to 1.0] in the THS group vs. 2.0 [range 2.0 to 2.0] in the ZES group vs. 0.5 [range 0.0 to 2.0] in the BMS group, P<0.0001), and inflammation score (1.0 [range 0.0-1.0] in the THS group vs. 1.0 [range 1.0 to 2.0] in the ZES group vs. 1.0 [range 0.75 to 1.0] in the BMS group, P<0.0001) among the three groups. In-stent restenosis rate, as measured by micro computed tomography, demonstrated similar percent area values upon histology analysis (57.7±13.14% in the THS group vs. 58.7±16.44% in the ZES group 64.8±8.56% in the BMS group, P<0.05).
Conclusion
THS is more effective in reducing neointima formation compared to BMS. Moreover, the neointima suppressive effect of THS exceeds that of commercial ZES, with lower fibrin and inflammation scores in a porcine coronary restenosis model.
파일  87-Effect of a Non-polymer Titanium Dioxide Thin Film-Coated Stent with Heparin in a Porcine Coronary Restenosis Model..pdf (2.7M) DATE : 2018-05-28 11:11:34