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논문번호 97
논문제목(영문) Influence of Local Myocardial Infarction on Endothelial Function, Neointimal Progression, and Inflammation in Target and Non-Target Vascular Territories in a Porcine Model of Acute Myocardial Infarction
국내외구분 국내 SCI여부 SCI
연구책임자역할 교신저자
주저자명 Hyun Kuk Kim, Han Byul Kim
교신저자명 Myung Ho Jeong
공동저자명 Hyun Kuk Kim , 1* Han Byul Kim , 2* Joo Myung Lee , 3 Sung Soo Kim , 1 In Ho Bae , 2,4,5 Dae Sung Park , 2,4,5,6 Jun-Kyu Park , 7 Jae Won Shim , 2,4,5 Joo-Young Na , 8 Min Young Lee , 9 Joong Sun Kim , 10 Doo Sun Sim , 2,5 Young Joon Hong , 2 Chang-W
게제년월일 2019-05-20
ISSN 1011-8934
Impact Factor 1.588
학술지명 Journal of Korean medical science
서지사항 0집 / 34권 / 19호,   페이지(e145 - e145)
요약초록문
(Abstract) 입력		 Background: Patients with acute myocardial infarction (AMI) have worse clinical outcomes
than those with stable coronary artery disease despite revascularization. Non-culprit lesions
of AMI also involve more adverse cardiovascular events. This study aimed to investigate the
influence of AMI on endothelial function, neointimal progression, and inflammation in
target and non-target vessels.
Methods: In castrated male pigs, AMI was induced by balloon occlusion and reperfusion into
the left anterior descending artery (LAD). Everolimus-eluting stents (EES) were implanted
in the LAD and left circumflex (LCX) artery 2 days after AMI induction. In the control
group, EES were implanted in the LAD and LCX in a similar fashion without AMI induction.
Endothelial function was assessed using acetylcholine infusion before enrollment, after the
AMI or sham operation, and at 1 month follow-up. A histological examination was conducted
1 month after stenting.
Results: A total of 10 pigs implanted with 20 EES in the LAD and LCX were included.
Significant paradoxical vasoconstriction was assessed after acetylcholine challenge in the
AMI group compared with the control group. In the histologic analysis, the AMI group
showed a larger neointimal area and larger area of stenosis than the control group after EES
implantation. Peri-strut inflammation and fibrin formation were significant in the AMI group
without differences in injury score. The non-target vessel of the AMI also showed similar
findings to the target vessel compared with the control group.
Conclusion: In the pig model, AMI events induced endothelial dysfunction, inflammation,
and neointimal progression in the target and non-target vessels.
파일  B97.Influence_of_Local_Myocardial_Infarction_on_Endoth.pdf (7.5M) DATE : 2021-05-27 15:41:05