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논문번호 98
논문제목(영문) Novel porcine model of acute myocardial infarction using polyethylene terephthalate
국내외구분 국내 SCI여부 KCI
연구책임자역할 교신저자
주저자명 Yong Sook Kim
교신저자명 Myung Ho Jeong, Kyung Seob Lim
공동저자명 Yong Sook Kim1,2† , Nan Yeol Kim3† , In-Ho Bae1,2,4 , Jun Kyu Park5 , Dae Sung Park1,2,4,6 , Jae Won Shim1,2,4 , Wan Suk Kang1,2 , Han Byul Kim1,2 , Bong-Seok Song7 , Bon-Sang Koo7 , Kang-Jin Jeong7 , Sun-Uk Kim7 , Hyun Kuk Kim8 , Sung Soo Kim8 , Min Chul
게제년월일 2019-06-20
ISSN 2508-139X
Impact Factor 0.1
학술지명 Journal of Biomedical and Translational Research
서지사항 0집 / 20권 / 2호,   페이지(44 - 52)
요약초록문
(Abstract) 입력		 Acute myocardial infarction (AMI) is considered the major
cause of mortality in the world. Tremendous animal
studies are performed to develop novel therapeutics, and
this study aimed to induce porcine myocardial infarction
model by using polyethylene terephthalate (PET). Coronary
guidewire was placed in left anterior descending artery
(LAD). The balloon angioplasty catheter was inserted at
the back of the PET. The balloon catheter was carefully
pushed forward, until the balloon marker was located in
mid-LAD. Coronary angiography was performed pre- and
post-occlusion at 28 days by C-arm. Histologic analysis
of heart tissue was performed 28 days after inducing AMI. Thirty three pigs were anesthetized and underwent percutaneous coronary catheterization. All pigs were successfully
embolized in mid-LAD by PET. Fifteen pigs died due to
ventricular fibrillation during post-anesthetic recovery time,
and overall experiment mortality was 45.5%. In 2,3,5-
triphenyl tetrazolium chloride staining, gross finding of
the ischemic heart lesion showed firm and white area of
infarction associated with the apex and left ventricular
posterior wall. Infarct on H&E-stained sections demon- strated a region without myocytes and rich with cardio- myocyte with atypical nuclei. Successful induction of
AMI by using PET may provide the pathophysiological
information of ischemic heart disease and improvement
of therapy development for AMI.
파일  B98. Novel porcine model of acute myocardial infarction using polyethylene terephthalate (1).pdf (4.3M) DATE : 2021-05-27 16:01:19