B58. Lim KS, Park JK, Jeong MH, Nah JW, Kim DG, Bae IH, Park DS, Kim JM, Kim JH, Cho DL, Sim DS, Park KH, Hong YJ, Ahn Y; Comparison of Sirolimus Loaded PLGA-PEG Co-polymer Coronary Stent and Bare Metal Stent in Porcine Coronary Restenosis Model. Macromol Res. 2014;22(6)639-646.
(Abstract)
The aim of this study was to compare the effect of the sirolimus loaded PLGA-PEG co-polymer coronary stent with that of the bare metal stent in a porcine coronary restenosis model. Pigs were randomized into two groups (10 pigs, 10 coronary arteries in each group), in which either the sirolimus loaded PLGA-PEG copolymer stent (SPPS, n=10) or the bare metal stent (BMS, n=10) was implanted in the coronary arteries. Histopathologic analysis was performed at 28 days after stenting. There were no significant differences in the injury score, internal elastic lamina (IEL) area, and inflammation score between the two groups. There were significant differences in the lumen area (3.6±0.42 mm2 in the SPPS group vs. 2.5±0.89 mm2 in the BMS group, p<0.001), in the neointimal area (1.2±0.34 mm2 in the SPPS group vs. 2.5±0.99 mm2 in the BMS group, p<0.001), in the percent area stenosis (26.0±6.58% in the SPPS group vs. 48.6±16.95% in the BMS group, p<0.001) and in the fibrin score (1.2±0.41 in the SPPS group vs. 0.5±0.26 in the BMS group, p<0.001). These results demonstrate that SPPS had a superior effect on suppression of neointimal hyperplasia than BMS at one month after stenting in a porcine coronary restenosis model.
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DATE : 16-03-13 12:37
HIT : 1,496
