B9. Lee DC, Jeong MH, Kim KH, Lee HS, Bom HS, Hong YD, Choi SJ, Park KB, Kim EH, Cho JG, Park JC, Kang JC; The Effects of 166Ho-Loaded Radioactive Stent in a Porcine Model. Korean Circulation J 2002;32(6)479-484.
(Abstract)
Background and Objectives：Vascular brachytherpy known to be an effective method in the prevention of restenosis following percutaneous coronary intervention (PCI). In this study we observed the effects of a radioisotope-loaded stent in a porcine model.
Materials and Methods：Holmium-166 (166Ho) was loaded onto the stent surface using impregnated polyurethane, and placed the stents into 7 porcine coronary arteries. Four weeks after stent overdilation injury, histopathological examination was performed.
Results：The absorbed dose of 166Ho to the coronary artery, from the 158.5±140.9 μCi 166Ho stent, was about 141 Gy at a depth of 0.5 mm, which was calculated by Monte Carlo EGS 4 Code. The mean external, and internal elastic lamina areas, the luminal and neointimal areas and the histopathological area stenosis in the 7 porcine coronary arteries were 7.6±2.8 mm2, 4.7±1.6 mm2, 2.4±1.4 mm2, 2.3±1.6 mm2 and 49.4±24.9%, respectively. The histopathological findings revealed remarkable inflammatory reactions and thrombosis in two of the porcine coronary arteries.
Conclusion：166Ho radioactive loaded stents, using impregnated polyurethane, may inhibit neointimal hyperplasia, but the problems of stent thrombosis and inflammation should be solved.
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DATE : 16-03-13 11:50
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