B10. Kim W, Jeong MH, Lee SR, Park OY, Kim JH, Jeong WK, Rhew JY, Kim JH, Yum JH, Bom HS, Choi SJ, Park KB, Ahn YK, Park JT, Cho JG, Park JC, Kang JC; The Effects of Beta-Radiation Using a Holmium-166 Coated Balloon on Neointimal Hyperplasia in a Porcine Coronary Stent Restenosis Model. Korean Circulation J 2002;32(5)398-406.
(Abstract)
Background and Objectives：Brachytherapy is a promising method in the prevention and treatment of coronary stent restenosis. We sought to observe the therapeutic effects of a radioactive balloon loaded with Holmium- 166 (166Ho) in a porcine coronary stent restenosis model.
Materials and Methods：A radioisotope of 166Ho was coated on the balloon surface using a polyurethane coating (20 Gy in 0.5 mm depth). Stent overdilation injuries were performed in two coronary arteries in 8 pigs. Four weeks after the stent overdilation injury, radiation therapies were performed using a control balloon dilation in one coronary artery (Group I：n＝8) and a 166Ho-coated balloon in the other coronary artery in each pig (Group II：n＝8). Follow-up coronary angiogram and histopathologic assessment were performed at 4 weeks after the therepy was administered.
Results：Laboratory findings did not differ significantly between the pre-treatment baseline and the measurements taken after radiation. On quantitative coronary angiogram, the coronary artery diameters were not significantly different between the two groups before stenting or at 4 and 8 weeks after stenting. On histopathologic analysis, injury score, internal elastic lamina area and lumen area did not differ significantly between the two groups. The neointimal area was 1.78±0.11 mm2 in group I and 1.36±0.12 mm2 in group II (p＝0.017), and the histopathologic area of stenosis was 35.1±1.6% in Group I, 27.6±1.9% in Group II (p＝0.005).
Conclusion：A treatment of beta-radiation in a stented porcine coronary artery using radioactive Ho-166 coated balloon inhibits stent restenosis without any side effects
KEY WORDS：Coronary disease；Coronary restenosis；Stents；Radioisotopes.
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DATE : 16-03-13 11:52
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