DATE : 16-03-13 12:00
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The effect of the carvedilol-loaded BiodivYsioTM DD stent on the inhibition of neointimal proliferation in a porcine coronary stent restenosis model.
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WRITER :
stent
 HIT : 2,941
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 B18._Korean_J_Med_2004;66_1_48-57..pdf (524.9K) [0] DATE : 2016-03-13 12:00:08 |
B18. Kim W, Jeong MH, Cha KS, Lee SH, Hong YJ, Kim JH, Ahn Y, Park OY, Kim MH, Cho JG, Park JC, Kang JC; The effect of the carvedilol-loaded BiodivYsioTM DD stent on the inhibition of neointimal proliferation in a porcine coronary stent restenosis model. Korean J Med 2004;66(1)48-57.
(Abstract)
BACKGROUND: Carvedilol is a beta- and alpha-receptor blocker, a direct inhibitor of smooth muscle cell proliferation and migration, and produces a significant suppression of neointimal hyperplasia in rat carotid injury model. We tested whether carvedilol stent coating is effective in preventing neointimal formation in a porcine model of stent restenosis.
METHODS: BiodivYsio phosphorylcholine-coated stents were dip-coated with carvedilol at the concentrations of 0, 7, 96 and 154 micrometer/stent by the immersion in a methanolic carvedilol followed by the evaporation of the solvent. Thirty-two stents, 8 stents per each concentration, were deployed in the porcine coronary arteries. The treatment effect was assessed at 28 days after stent implantation.
RESULTS: Angiographic minimal lumen diameter and late loss index were similar among the four groups. On histomorphometry, neointimal area decreased by 58% and lumen area increased by 20%, resulting in a 58% reduction of percent in-stent stenosis in 7 micrometer carvedilol/stent (p=0.002, 0.008 and 0.004, respectively, 7 micrometer vs. 0 micrometer carvedilol/stent). Modest change in neointimal and lumen area was observed in 96 and 154 micrometer carvedilol/stent. A proliferating nuclear cell antigen-positive cells was noted 7.78 +/- 2.97% in 7 micrometer carvedilol/stent vs. 17.82 +/- 1.45% in 0 micrometer carvedilol/stent (p=0.0001).
CONCLUSION: A Low dose carvedilol stent coating produces a significant inhibition of neointimal hyperplasia in a porcine model of stent restenosis. This study provides a potential therapeutic benefit of carvedilol coating in the prevention of human stent restenosis.
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