B15. Park OY, Jeong MH, Kim JH, Kim W, Lee SH, Hong YJ, Kim JH, Park WS, KimI S, Choi MJ, AhnY, Park JT, Cho JG, ChoDL, Park JC, Kang JC; The Inhibitory Effects of Platelet Glycoprotein IIb/IIIa Receptor Blocker-Coated Stent on Neointima Formation and Inflammatory Response in Porcine Coronary Stent Restenosis. Korean Circulation J 2003;33(5)439-445.
(Abstract)
Background and Objectives：Previously, we reported that Abciximab (ReoPro®)-coated stent inhibited in-stent neointimal hyperplasia. ReoPro® is known to suppress vascular inflammation through CD 11b/18 (macrophage-1 receptor). We observed inhibitory effects of neointima formation and inflammatory reaction after stenting in a porcine model.
Materials and Methods：The surface of the stent was coated with ReoPro® by means of plasma polymerization followed by chemical grafting. Stent overdilation injury was performed with control bare stent (Group I, n=13) and ReoPro®-coated stents (Group II, n=13) in 26 porcine coronary arteries. Follow-up coronary angiogram and the histopathologic assessments of stented porcine coronary were performed on day 14 (Group I：n=6, Group II：n=6) and day 28 (Group I：n=7, Group II：n=7) after stenting.
Results：Pathologic area stenosis was 19.7±5.3% in Group I and 15.9±3.3% in Group II at day 14, and 33.6±27.7% and 22.6±6.6%, respectively, at day 28 (p<0.05 at day 28). The ratio of inflammatory cells out of the number of total cells in the neointima was 21.8±6.5% in Group I and 22.5±11.6% in Group II at day 14, and 27.3±18.3% in Group I and 28.6±10.7% in Group II at day 28 post stenting (p=NS). And those of the media were 2.89±1.13% in Group I and 1.36±1.27% in Group II at day 14, and 6.61±5.61% and 6.26±4.51% at day 28 (p=NS). Fibrinoid materials associated with inflammatory reaction were observed in both groups at days 14 and 28.
Conclusion：An inflammatory reaction was not suppressed with the use of ReoPro®-coated stenting in a porcine stent restenosis model.
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DATE : 16-03-13 11:57
HIT : 1,336
