DATE : 16-03-13 12:11
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Preparation of biocompatible stent surface by plasma polymeration followed by chemical grafting of drug compounds.
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WRITER :
stent
 HIT : 1,314
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 B30._J._Mater._Chem.,_2009;19_20_3248–3252..pdf (1.0M) [0] DATE : 2016-03-13 12:11:53 |
B30. Song SJ, Kim SK, Kim KH, Li HJ, Lim GT, Jeong MH, Kim JH, Kim BH, Ko YM, Cho DL; Preparation of biocompatible stent surface by plasma polymeration followed by chemical grafting of drug compounds. J. Mater. Chem. 2009;19(20)3248–3252.
(Abstract)
The preparation of a biocompatible stent surface was investigated by plasma polymerization of 1,2- diaminocyclohexane (DACH) followed by chemical grafting of a-lipoic acid (ALA). The plasma polymerization resulted in the deposition of a thin polymer film containing amine groups. ALA could be grafted chemically to the thin film through the formation of an amide bond in the presence of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide methiodide (carbodiimide). The ALA-grafted film showed good mechanical stability and blood compatibility, and a stent coated with the film was shown to be effective at inhibiting neointimal hyperplasia.
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