B3. Jeong MH, Kim W, Kim YR, Cho JH, Kim JW, Kim JH, Kim SH, Ahn YK, Park JH, Cho JG, Park CS, Park JC, Kang JC; The effects of local endothelin receptor blocker delivery on porcine coronary stent restenosis. Kor J Int Med 1999;56(6)691-700.
(Abstract)
Objectives : Coronary stent is one of the most effective currently available devices in the treatment of coronary artery diseases. But, coronary stent restenosis is one of major limitations in clinical stenting. Local drug delivery m ay be a new strategy for the prevention of stent restenosis. En dothelin receptor blocker is known to have vaso dilatory and ant I proliferative activities. To investigate the effects of local endothelin receptor blocker delivery on stent restenosis, local de livery was per formed in the porcine model of coronary stent restenosis.
Methods : Stent over dilation injury a lone was performed in the control porcine coronary arteries (n=4, group A) and local de livery of endo the lin receptor blocker prior to stenting was performed in the porcine coronary artery (n=9, group B). En doth elinreceptor blocker (TAK- 044, Takeda, Japan ) was deliverey data rate of 1 ml/min (50 mg / 10 ml) using the Dispatch Catheter. Follow–up quantitative coronary angiogram (QCA) and immunohistopathologic assessment were per formed 4 weeks after stenting .
Results : 1) On QCA, percent diameter stenos is was significantly higher in Group A than in Group B (29.4±6.1 % vs. 14.5±11.6% , p< 0.05). 2) Area st enosis was higher in Group A than in Group B (63.5±23.2 % vs . 40.9±13.3 %) measured by histopa-thologic method (p< 0.05). 3) Neoint imal area was higher in Group A than in Group B (3.53±1.9 mm2 vs . 1.75±0.8 mm2, p=0.03). 4) By immunocytochemistry, proliferating cell n uclear antigen index was higher in Group A compared with Group B (46.8±5.2 % vs . 31.1±3.7 %, p< 0.05).
Conclusion : Local delivery of endothelin receptor blocker is effective in the prevention of stent restenosis in a porcine model, which may be related with the partial inhibition of cell proliferation of neointimal cells .
|
DATE : 16-03-13 11:44
HIT : 1,582
