B8. Kang KT, Jeong MH, Kim NH, Rhew JY, Lee SH, Park JC, Lee SU, Kim KH, Choi MJ. Ahn Y, Cho JG, Park JC, Choi WJ, Cho DL, Kang JC; The inhibitory effect of platelet glycoprotein IIb/IIIa receptor blocker-coated stent on porcine coronary stent restenosis. Korean J Med 2001;60(4)314-323.
(Abstract)
Background : The problems of coronary stent thrombosis and restenosis still remain to be solved. The glycoprotein IIb/ IIIa receptor blocker, Abciximab (ReoPro), plays important roles in the treatment of high- risk patient with acute platelet - rich thrombus and in the inhibition of smooth muscle cell proliferation. The aim of this study was to determine whether the use of ReoPro- coated stents could reduce the neointimal formation in a porcine coronary stent restenosis model.
Methods : ReoPro was coated on the surface of stent by means of plasma polymerization followed by chemical grafting . Stent overdilation injury was performed with control bare stent (Group I, n=13), and ReoPro- coated stents (Group II, n=14). Follow- up quantitative coronary angiogram was performed at 4 weeks after stenting and histopathologic assessment were compared in both groups.
Results : The diameter stenosis by QCA between two groups was significantly higher in Group I (23±5 % vs. 15±7 %, p =0.003). On histopathologic examination, no in- stent thrombus was observed. The percent area stenosis was significantly higher in Group I than in Group II (48±17 % vs. 30±16 %, p =0.01). The area of neoinima was larger in Group I than in Group II (3.2±1.2 mm2 vs. 2.0±1.0 mm2 , p =0.01). By immunocytochemistry, proliferation cell nuclear antigen indices were higher in Group I (4.2±2.1 %, vs 2.4±1.8 % p =0.03).
|
DATE : 16-03-13 11:49
HIT : 899
