Philyong Kang1† , Hwal-Yong Lee1† , Hee Chang Son1 , Sung Hyun Park1 , Won Seok Choi1 , Bon Sang Koo1 , Chang-Yeop Jeon1 , Seug Ho Baek1 , You Jung An1 , Hyun Kuk Kim2 , Sung Soo Kim2 , Jun Kyu Park3 , In Ho Bae4,5 , Dae Sung Park4,5,6 , Jae Won Shim4,5
Effect of dyslipidemia on vascular smooth muscle cell proliferation in a porcine coronary restenosis model
Journal of Biomedical and Translational Research
This study aimed to examine the effect of a mild ele- vation in serum cholesterol level in a porcine coronary overstretch restenosis model using a balloon angioplasty catheter or drug-eluting coronary stent. Pigs were divided into two groups and were fed a commercial normal diet (CND, n = 4) or a high-fat diet (HFD, n = 4) for 5 weeks. Coronary overstretch injury by balloon angioplasty or stent implantation was induced in the left anterior descending and left circumflex artery after 1 week of feeding. Histo- pathological analysis was performed at 4 weeks after coronary injury. During the experiment, the total cholesterol level in the HFD group increased by approximately 44.9% (from 65.9 ± 3.21 mg/dL at baseline to 95.5 ± 9.94 mg/dL at 5 weeks). The lumen area in the CND group was reduced in comparison with that in the HFD group after balloon angioplasty. After stent implantation, the injury score showed no significant difference. There were significant differences in the neointimal area (2.7 ± 0.33 mm2in the CND group vs. 3.3 ± 0.34 mm2in the HFD group, p<0.05), lumen area (2.6 ± 0.54 mm2in the CND group vs. 2.0 ± 0.33 mm2in the HFD group, p<0.05), and percent area stenosis (52.0 ± 7.96% in the CND group vs. 62.4 ± 5.15% in the HFD group, p<0.05). Body weight change was not different between the two groups. Increased serum cholesterol level activated vascular smooth muscle cell proliferation in the porcine coronary overstretch model.
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DATE : 21-06-10 11:58
HIT : 853
