B4. Park HW, Jeong MH, Jang YS, Kim YR, Kim W, Park WS, Kim NH, Kim JW, Kim SH, Cho JH, Ahn Y, Cho JG, Cho DL, Kim HJ, Park JC, Lee JH, Park CS, Kang JC; The effects of the heparin-coated maximum arterial re-creation (MAC) stent on porcine coronary stent restenosis. Korean Circulation J 1999;29(5)498-506.
(Abstract)
Background：Stent thrombosis and late restenosis are still major limitations in the clinical use of coronary stenting. Heparin-coated stent may reduce the incidences of stent thrombosis and restenosis. Heparin-coated stents were compared with control stents in a porcine coronary stent restenosis model in order to evaluate the effects of heparin-coated stent on stent restenosis.
Methods：Heparin was coated on a stent by deposition of an ultra-thin polymeric film containing amine groups by means of plasma polymerization. And then stent was immersed in heparin solution. Stent overdilation injury (stent：artery＝1.3：1.0) was performed with bare (Group Ⅰ, n＝4) and heparin-coated (Group Ⅱ, n＝5) MAC stents in porcine coronary arteries. Follow-up quantitative coronary angiography (QCA) was performed at 4 weeks after stenting. The histopathologic assessments of stented porcine coronary arteries were compared in between 2 groups.
Results：1) Luminal area of stented artery was 7.05±1.25 mm2 in Group Ⅰ and 7.67±2.85 mm2 in Group Ⅱ, which were not different between two Groups. 2) Histopathologic stenosis of Group Ⅰ was 35.7±13.2%, which was higher than 28.6±14.7% of Group Ⅱ (p<0.05). Ratio of neointima/media was 1.16±0.52 in Group Ⅰ and 0.87±0.31 in Group Ⅱ and neointimal area was higher in Group Ⅰ than in Group Ⅱ (3.81±1.78 mm2 vs. 2.82 ±1.11 mm2, p<0.05 respectively). 3) PCNA (Proliferating cell nuclear antigen) index of GroupⅠ was 10.0±2.2%, which was higher than in Group Ⅱ (6.8±4.0%).
Conclusions：Heparin-coated MAC stent may be effective in the inhibition of neointimal proliferation in a porcine stent restenosis model.
|
DATE : 16-03-13 11:45
HIT : 927
