C24. Rhew JY, Jeong MH, Hong YJ, Kim W, Kang KT, Lee SH, Park JC, Kim NH, Ahn YK, Cho JG, Park JC, Kang JC; The effect of Lipoprtein (a) on coronary stent restenosis. Korean Circulation J 2001;31(5)476-483.
(Abstract)
Background
Lipoprotein (a) [Lp(a)] contains apolipoprotein(a), which is a structural homologue of plasminogen and competes with it for binding sites. It also acts by increasing plasminogen activator inhibitor-1 expression. The objective of this study was to evaluate the relationship between Lp(a) levels and restenosis rate after successful coronary stent placement.
Methods
The study included 306 patients who underwent coronary stent placement and follow-up coronary angiogram at Chonnam National University Hospital from August 1996 to June 2000. Restenosis rate was analyzed according to the level of Lp(a); Group I with high Lp(a) (n=7, Lp(a) 36 mg/dL, 58.98.8 years, female: 35.1%) and Group II with low Lp(a) (n=29, Lp(a) < 36 mg/dL, 57.79.8 years, female: 18.8%).
Results
1) There was no significant differences in risk factors of atherosclerosis, clinical diagnosis, the number of involved coronary artery, left ventricular function, angiographic lesion characteristics by American College of Cardiology/American Heart Association clasification and Thrombolysis In Myocardial Infarction flow in two groups. 2) Angiographic restenosis rates were not different between two groups (group I : 33.8%, group II : 35.4%).
Conclusion
Plasma Lp(a) levels are not related with the angiographic restenosis rate after coronary stent placement.
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DATE : 16-03-14 13:07
HIT : 4,262
