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논문번호 17
논문제목(영문) The Effects of Probucol Combined with Antiplatelets on the Coronary Stented Patients.
국내외구분 국내 SCI여부 SCI(E)
연구책임자역할 교신저자
주저자명 Kim NH
교신저자명 Jeong MH
공동저자명 Kim NH, Jeong MH, Kim W, Kim YR, Lee SU, Kim KH, Cho JH, Park JC, Na KJ, Ahn Y, Cho JG, Ahn BH, Park JC, Kang JC;
게제년월일 2000-05-25
ISSN 1738-5520
Impact Factor 0.753
학술지명 Korean Circulation J
서지사항 0집 / 30권 / 7호,   페이지(811 - 818)
요약초록문
(Abstract) 입력		 Background：An antioxidant, probucol, prevents endothelial dysfunction and low density lipoprotein oxidation and also inhibits the secretion of interleukin-1 by macrophages. These effects of probucol may result in decreased production of matrix metalloproteinases by smooth muscle cells and thus modify remodeling of the extracellular matrix.
Methods and Materials：We analyzed clinical events at 1 month and 6 months in 337 patients with 363 coronary arterial lesions after coronary stenting at Chonnam National University Hospital between January 1998 and May 1999. The patients were assigned to following four modalities：500 mg of tilcipidine daily (GroupⅠ), 200 mg of cilostazol daily (Group Ⅱ), 500 mg of probucol in addition to 500 mg of ticlipidine daily (Group Ⅲ), and 500 mg of probucol in addition to 200 mg of cilostazol daily (Group Ⅳ). All patients received aspirin.
Results：GroupⅠcomprised of 149 (104 M, 45 F, 62±10 years), Group Ⅱ 96 (73 M, 23 F, 60±10 years), Group Ⅲ 50 (32 M, 18 F, 61±10 years), and Group Ⅳ 42 (32 M, 10 F, 62±10 years) patients. Clinical diagnosis was not different among four groups. Major adverse cardiac events, including myocardial infarction, cardiac death, and repeated intervention, at 1 month were 7 (4.7%) in Group Ⅰ, 2 (2.1%) in Group Ⅱ, 0 (0%) in Group Ⅲ, 2 patients (4.8%) in Group Ⅳ, and those at 6 months were 29 (19.5%) in GroupⅠ, 17 (17.7%) in Group Ⅱ, 9 (18.0%) in Group Ⅲ, and 6 patients (14.3%) in Group Ⅳ.
Conclusions：Probucol combined with aspirin and cilostazol has a tendency reducing the major cardiac events compared with aspirin and ticlopidine or cilostazol after stenting.
파일  C15. Korean Circulation J 2000;30(7)811-818..pdf (278.1K) DATE : 2016-03-14 11:48:55