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논문번호 44
논문제목(영문) The Effects of a Carbon Ion Implantation Technique on In-stent Restenosis: Korean Multicentered Randomized Trial.
국내외구분 국내 SCI여부 SCI(E)
연구책임자역할 공저자
주저자명 Tahk SJ
교신저자명 Tahk SJ
공동저자명 Tahk SJ, Choi SY, Choi BJ, Kim KB, Kim BO, Kim SW, Kim CJ, Park KS, Seung KB, Seong IW, Yang JU, Yoon J, Lee SH, Jang Y, Jeong MH, Cheong SS;
게제년월일 2004-01-30
ISSN 1738-5520
Impact Factor 0.753
학술지명 Korean Circulation J
서지사항 0집 / 34권 / 5호,   페이지(477 - 484)
요약초록문
(Abstract) 입력		 Background and Objectives：Heavy metal ions released from a stainless steel stent can induce an inflammatory reaction that might be associated with in-stent restenosis. A carbon ion implantation technique, which physically integrates carbon ions into the surface of the stainless steel lattice, can block heavy metal ion diffusion, and improve the biocompatibility. This study was designed to evaluate the efficacy of a carbon ion implanted Arthosinert stent on the reduction of in-stent restenosis and the improvement in the clinical outcomes.
Subjects and Methods：193 de novo coronary lesions in 191 anginal patients at 14 centers, with reference diameters from 2.75 to 4.5 mm, were randomly assigned to either an Arthosinert (100 patients, 102 lesions) or an Arthos (91 patients, 91 lesions) stent. The lesion length was 14.1±5.7 mm. The ACC/AHA (American College of Cardiology/American Heart Association) lesion classifications were A：15.0%, B1：36.8%, B2：35.8% and C：12.4%. The study end points are angiographic restenosis, during a six-month follow-up, and Major adverse cardiac event. In-stent restenosis was defined as a diameter of stenosis ≥50%.
Results：A six-month angiographic follow-up was obtained for 72.3% (138/191) of the subjects. There were no significant differences between the Arthosinert and Arthos groups in the rates of restenosis (17.8% vs. 31.8%, p=0.055) and Target vessel revascularization (7.0% vs. 11.0%, p=0.476). There were no deaths or non-fatal myocardial infarction in either group.
Conclusion：The treatment of de novo coronary stenosis, with carbon ion implanted stents, showed a tendency for lower six-month angiographic restenosis rates than the conventional 316L stainless steel stents. A larger trial will be needed to confirm the efficacy of the carbon ion implanted stent.
파일  C44.+Korean+Circ+J.+2004;34(5)477-484..pdf (586.6K) DATE : 2021-05-21 16:30:02