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논문제목(영문) Preinterventional peak monocyte count and in-stent intimal hyperplasia after coronary stent implantation in human coronary arteries.
국내외구분 국외 SCI여부 SCI(E)
연구책임자역할 교신저자
주저자명 Hong YJ
교신저자명 Jeong MH
공동저자명 Hong YJ, Jeong MH, Lim SY, Lee SR, Kim KH, Sohn IS, Park HW, Kim JH, Kim W, Ahn Y, Cho JG, Park JC, Kang JC;
게제년월일 2005-08-16
ISSN 0160-9289
Impact Factor 2.586
학술지명 Clinical cardiology
서지사항 0집 / 28권 / 11호,   페이지(512 - 518)
요약초록문
(Abstract) 입력		 BACKGROUND:
The mechanism of restenosis after stent implantation principally is neointimal hyperplasia. There is evidence that monocytes play a important role in in-stent restenosis (ISR) after stent implantation.
HYPOTHESIS:
This study assessed the relationship between preinterventional peak monocyte count and neointimal growth after successful stent implantation.
METHODS:
We performed coronary stent implantation in 85 patients (85 de novo lesions). Peripheral blood sample was obtained in all patients every 12 h before coronary angiography for measurement of peripheral monocytes. All patients received angiographic and intravascular ultrasound (IVUS) follow-up at 6 months after stenting.
RESULTS:
The preinterventional circulating monocyte count was significantly higher in the ISR group than that in the group without ISR (654 +/- 62/vs. 461 +/- 222/mm3, p < 0.001) and was significantly higher in the reintervention group than that in the no-reintervention group (660 +/- 72/ vs. 470 +/- 216/mm3, p< 0.001). The incidence of ISR and repeat intervention associated with preinterventional monocyte count was highest among the patients in the highest tertile, who were at a 2.64-fold increased risk of ISR and 3.22-fold increased risk of repeat intervention compared with the patients in the lowest tertile. A significant positive correlation was found between preinterventional peak monocyte count and preinterventional plaque and media cross-sectional area and follow-up neointima area (r = 0.311, p = 0.007, r = 0.465, p < 0.001, respectively). The neointima area associated with preinterventional monocyte count was largest among the patients in the highest tertile, that is, 2-fold larger than that of the patients in the lowest tertile (p < 0.001) and 1.44-fold larger than that of the patients in the middle tertile (p = 0.001).
CONCLUSION:
Our results suggest that circulating preinterventional monocytes play a principal role in the process of in-stent neointimal growth after successful stent implantation.
파일  C50.+Clin+Cardiol.+2005;28(11)512-518..pdf (109.6K) DATE : 2021-05-21 16:34:47