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논문번호 70
논문제목(영문) Effects of long-term triple anti-platelet therapy with low-dose cilostazol after drug-eluting stent implantation.
국내외구분 국내 SCI여부 SCI
연구책임자역할 공저자
주저자명 Kim DH
교신저자명 Kim JY
공동저자명 Kim DH, Kim JY, Moon SW, Jung JH, Yang HS, Cho JH, Jeong MH;
게제년월일 2007-8-21
ISSN 1011-8934
Impact Factor 1.266
학술지명 The Korean Journal of Medicine
서지사항 0집 / 74권 / 4호,   페이지(368 - 375)
요약초록문
(Abstract) 입력		 Background/Aims : A recent clinical trial demonstrated that triple anti platelet therapy resulted in significantly larger minimal luminal diameter and lower restenosis rate compared with conventional therapy after bare metal stent (BMS) implantation. However, it is uncertain that this result will be repeated after drug eluting stent (DES) implantation, especially with low dose cilostazol therapy. Thus, we performed a prospective, randomized study to evaluate the effectiveness of long term triple therapy with low dose cilostazol after DES implantation.
Methods : We analyzed 109 patients (132 lesion) prospectively, who underwent successful coronary DES implantation. The patients were divided into two groups according to combined anti platelet regimen: triple combination of aspirin, clopidogrel, and low dose cilostazol (50 mg/bid) (Group I, n=56) or dual combination of aspirin and clopidogrel (Group II, n=53) for 6 months. The minimal luminal diameter and binary restenosis rate were compared at 6 month follow up by coronary angiogram. The rates of stent thrombosis, major adverse cardiac events (MACE), and bleeding complication were also analyzed.
Results : The baseline clinical and angiographic characteristics were not different between the two groups. Angiographic follow up was performed in 80 patients (109 lesions, 74%). The minimal luminal diameter at 6 month was 2.25±0.63 mm in group I and 2.30±0.56 mm in group II (p=0.742). Restenosis occurred in 4 patients (7.2%) in group I and 3 patients (5.6%) in group II (p=0.611). There were no differences in the rates of stent thrombosis, MACE, or bleeding complications between the two groups.
Conclusions : Long term triple anti platelet therapy with low dose cilostazol after DES implantation was not effective in obtaining larger minimal luminal diameter or reducing restenosis rate, but it was used safely without increasing bleeding complication.
파일  C70.+Korean+J+Med+2008;74(4)368-375..pdf (292.0K) DATE : 2021-05-21 16:52:56