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논문번호 83
논문제목(영문) Usual dose of simvastatin does not inhibit plaque progression and lumen loss at the peri-stent reference segments after bare-metal stent implantation: a serial intravascular ultrasound analysis.
국내외구분 국내 SCI여부 SCI
연구책임자역할 교신저자
주저자명 Hong YJ
교신저자명 Jeong MH
공동저자명 Hong YJ, Jeong MH, Choi YH, Ma EH, Ko JS, Lee MG, Park KH, Sim DS, Yoon NS, Youn HJ, Kim KH, Park HW, Kim JH, Ahn Y, Cho JG, Park JC, Kang JC;
게제년월일 2010-06-11
ISSN 1226-3303
Impact Factor 1.426
학술지명 The Korean journal of internal medicine
서지사항 0집 / 25권 / 4호,   페이지(356 - 363)
요약초록문
(Abstract) 입력		 BACKGROUND/AIMS:
The aim of this study was to assess the effects of a usual dose of simvastatin (20 mg/day) on plaque regression and vascular remodeling at the peri-stent reference segments after bare-metal stent implantation.
METHODS:
We retrospectively investigated serial intravascular ultrasound (IVUS) findings in 380 peri-stent reference segments (184 proximal and 196 distal to the stent) in 196 patients (simvastatin group, n = 132 vs. non-statin group, n = 64). Quantitative volumetric IVUS analysis was performed in 5-mm vessel segments proximal and distal to the stent.
RESULTS:
IVUS follow-up was performed at a mean of 9.4 months after stenting (range, 5 to 19 months). No significant differences were observed in the changes in mean plaque plus media (P&M) area, mean lumen area, and mean external elastic membrane (EEM) area from post-stenting to follow-up at both proximal and distal edges between the simvastatin and non-statin group. Although lumen loss within the first 3 mm from each stent edge was primarily due to an increase in P&M area rather than a change in EEM area, and lumen loss beyond 3 mm from each stent edge was due to a combination of increased P&M area and decreased EEM area, no significant differences in changes were observed in P&M, EEM, and lumen area at every 1-mm subsegment between the simvastatin and non-statin group.
CONCLUSIONS:
A usual dose of simvastatin does not inhibit plaque progression and lumen loss and does not affect vascular remodeling in peri-stent reference segments in patients undergoing bare-metal stent implantation.
파일  C83.+Korean+J+Intern+Med.+2010;25(4)356-363..pdf (542.6K) DATE : 2021-05-25 11:34:05