임상

HOME > 연구실적 > 임상 > 논문
 
작성일 : 16-03-13 23:52
논문번호 101
논문제목(영문) What is the optimal duration of triple anti-platelet therapy in patients with acute myocardial infarction undergoing drug-eluting stent implantation?
국내외구분 국외 SCI여부 SCI(E)
연구책임자역할 교신저자
주저자명 Park KH
교신저자명 Jeong MH
공동저자명 Park KH, Jeong MH, Lee MG, Ko JS, Sim DS, Yoon NS, Yoon HJ, Hong YJ, Kim KH, Park HW, Kim JH, Ahn Y, Cho JG, Park JC, Kang JC;
게제년월일 2010-10-08
ISSN 0914-5087
Impact Factor 2.782
학술지명 Journal of cardiology
서지사항 0집 / 57권 / 1호,   페이지(53 - 60)
요약초록문
(Abstract) 입력		 BACKGROUND:
The optimal duration of triple anti-platelet therapy (DTAP) remains unclear in patients with acute myocardial infarction (AMI).
METHODS:
We retrospectively analyzed 716 AMI patients who received TAP (aspirin, clopidogrel, and cilostazol) after drug-eluting stent (DES) implantation from November 2005 to May 2008. Mean age was 61.9 ± 11.70 years (male gender 74.1%) and mean duration of TAP was 98.1 ± 115.34 days. We compared the major adverse cardiovascular events [MACE, defined as the composite of cardiac death, non-fatal AMI, stent thrombosis, and target vessel revascularization (TVR)] between the group of DTAP ≥ 3 months (n = 497) and those of < 3 months (n = 219).
RESULTS:
There were no significant differences in the incidences of cardiac death, non-fatal AMI, stent thrombosis, and TVR at 1-year follow-up between the two groups. However, the group of DTAP ≥ 3 months had lower incidence of MACE than those < 3 months (5.9% vs. 10.7%, p = 0.044). The rate of bleeding complications was similar between the two groups. By Cox regression analysis with propensity score adjustment, Killip class IV and DTAP ≥ 3 months were independent predictors of 1-year MACE [hazard ratio (HR) = 10.417; 95% confidence interval (CI) = 1.587-68.377, p = 0.015 and HR = 0.508; 95% CI = 0.269-0.956, p = 0.036].
CONCLUSIONS:
Our data show that the DTAP ≥ 3 months is associated with better clinical outcomes compared with that of < 3 months in patients with AMI undergoing DES implantation without increasing bleeding complications.
파일  C101.+J+Cardiol.+2011;57(1)53-60..pdf (260.2K) DATE : 2021-05-25 14:26:24