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논문번호 117
논문제목(영문) Characteristics and predictors of drug-eluting stent thrombosis: results from the multicenter 'Korea Stent Thrombosis (KoST)' registry.
국내외구분 국외 SCI여부 SCI(E)
연구책임자역할 공저자
주저자명 Park KW, Hwang SJ
교신저자명 Kim HS
공동저자명 Park KW, Hwang SJ, Kwon DA, Oh BH, Park YB, Chae IH, Gwon HC, Park SJ, Seung KB, Ahn T, Yoon JH, Jang YS, Jeong MH, Tahk SJ, Kim HS;
게제년월일 2011-03-07
ISSN 1346-9843
Impact Factor 3.940
학술지명 Circulation Journal
서지사항 0집 / 75권 / 7호,   페이지(1626 - 1632)
요약초록문
(Abstract) 입력		 Abstract:
BACKGROUND: Previous studies have reported possible predictors of drug-eluting stent thrombosis (ST), but data for Asians are relatively limited. This study was performed to elucidate clinical predictors of ST in Koreans.
METHODS AND RESULTS: From May 2003 to May 2007, consecutive patients presenting with ST were enrolled from 10 cardiovascular centers in Korea. They were compared with 2,192 controls (3,223 lesions) who had received percutaneous coronary intervention with at least 6 months of follow-up without ST. On multivariate analysis, acute myocardial infarction (AMI) as initial diagnosis, drug-eluting stents (DES) in-stent restenosis (ISR), low ejection fraction (EF), small stent diameter, left anterior descending artery intervention, and young age were independent predictors of total ST. When divided into early (ST within 30 days of index procedure) and delayed ST (ST after 30 days of index procedure), low EF, small stent diameter, DES ISR and AMI as initial diagnosis were universal risks for both early and delayed ST. The time from antiplatelet agent discontinuation to ST occurrence was significantly shorter in late compared with very late ST.
CONCLUSIONS: Predictors of ST may be slightly different for early vs. delayed ST. However, low EF, small stent diameter, DES ISR lesion, and AMI as initial diagnosis were universal risk factors for both early and delayed ST cases. The relationship between antiplatelet agent discontinuation and ST occurrence seems stronger in late compared with very late ST.
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