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논문번호 127
논문제목(영문) The sirolimus-eluting Cypher Select coronary stent for the treatment of bare-metal and drug-eluting stent restenosis: insights from the e-SELECT (Multicenter Post-Market Surveillance) registry.
국내외구분 국외 SCI여부 SCI(E)
연구책임자역할 공저자
주저자명 Abizaid A
교신저자명 Abizaid A
공동저자명 Abizaid A, Costa JR Jr, Banning A, Bartorelli AL, Dzavik V, Ellis S, Gao R, Holmes DR Jr, Jeong MH, Legrand V, Neumann FJ, Nyakern M, Orlick A, Spaulding C, Worthley S, Urban PM;
게제년월일 2011-12-07
ISSN 1936-8798
Impact Factor 7.345
학술지명 JACC cardiovascular interventions
서지사항 0집 / 5권 / 1호,   페이지(64 - 71)
요약초록문
(Abstract) 입력		 Abstract:
OBJECTIVES: This study sought to compare the 1-year safety and efficacy of Cypher Select or Cypher Select Plus (Cordis Corporation, Bridgewater, New Jersey) sirolimus-eluting stents (SES) with the treatment of bare-metal stents (BMS) and drug-eluting stent (DES) in-stent restenosis (ISR) in nonselected, real-world patients.
BACKGROUND: There is paucity of consistent data on DES for the treatment of ISR, especially, DES ISR.
METHODS:
The e-SELECT (Multicenter Post-Market Surveillance) registry is a Web-based, multicenter and international registry encompassing virtually all subsets of patients and lesions treated with at least 1 SES during the period from 2006 to 2008. We enrolled in this pre-specified subanalysis all patients with at least 1 clinically relevant BMS or DES ISR treated with SES. Primary endpoint was major adverse cardiac events and stent thrombosis rate at 1 year.
RESULTS:
Of 15,147 patients enrolled, 1,590 (10.5%) presented at least 1 ISR (BMS group, n = 1,235, DES group, n = 355). Patients with DES ISR had higher incidence of diabetes (39.4% vs. 26.9%, p < 0.001), renal insufficiency (5.8% vs. 2.3%, p = 0.003), and prior coronary artery bypass graft (20.5% vs. 11.8%, p < 0.001). At 1 year, death (1.4% for BMS vs. 2.1% for DES, p = 0.3) and myocardial infarction (2.4% for BMS and 3.3% for DES, p = 0.3) rates were similar, whereas ischemia-driven target lesion revascularization and definite/probable late stent thrombosis were higher in patients with DES ISR (6.9% vs. 3.1%, p = 0.003, and 1.8% vs. 0.5%, p = 0.04, respectively).
CONCLUSIONS:Use of SES for either BMS or DES ISR treatment is safe and associated with low target lesion revascularization recurrence and no apparent safety concern.
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