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논문번호 130
논문제목(영문) Efficacy of drug-eluting stents for treating in-stent restenosis of drug-eluting stents (from the Korean DES ISR multicenter registry study [KISS]).
국내외구분 국외 SCI여부 SCI(E)
연구책임자역할 공저자
주저자명 Ko YG
교신저자명 Jang Y
공동저자명 Ko YG, Kim JS, Kim BK, Choi D, Hong MK, Jeon DW, Yang JY, Ahn YK, Jeong MH, Yu CW, Yun KH, Lim DS, Jang Y;
게제년월일 2011-10-21
ISSN 1879-1913
Impact Factor 3.276
학술지명 The American journal of cardiology
서지사항 0집 / 109권 / 5호,   페이지(607 - 613)
요약초록문
(Abstract) 입력		 Abstract: There is currently no established standard treatment for in-stent restenosis (ISR) after the implantation of a drug-eluting stent (DES). The aim of this study was to investigate the efficacy of DES versus balloon angioplasty (BA) for the treatment of DES ISR in a multicenter registry cohort. After matching propensity scores of 805 patients with DES ISR treated with either DES (n = 422) or BA (n = 383), 268 matched pairs were selected and analyzed for major adverse cardiac events, a composite of death, myocardial infarction, and target-vessel revascularization, as the primary end point. Baseline clinical and lesion characteristics of the matched pairs were similar. Survival free of major adverse cardiac events at 2 years was higher with DES compared to BA (88.9% vs 78.7%, p <0.001), mainly because of higher TVR-free survival (92.4% vs 81.0%, p <0.001). Among various baseline variables, BA (hazard ratio 2.546, 95% confidence interval 1.412 to 4.593, p = 0.002) was the most important independent risk factor for recurrent target vessel revascularization, followed by acute coronary syndromes as the clinical presentation of DES ISR, and previous implantation of a sirolimus-eluting stent. Survival free of death, myocardial infarction, or stent thrombosis did not differ between the 2 groups. Whereas there was no significant difference in survival free of target vessel revascularization between DES and BA for focal ISR lesions, DES was superior to BA in diffuse ISR lesions (94.3% vs 75.2% at 2 years, p <0.001). In conclusion, compared to BA, the implantation of DES was safe and more effective in the treatment of DES ISR.
파일  C130.+Am+J+Cardiol.+2012;109(5)607-613..pdf (449.8K) DATE : 2021-05-26 09:43:18