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논문번호 189
논문제목(영문) Impact of calcified bifurcation lesions in patients undergoing percutaneous coronary intervention using drug-eluting stents: Results from the COronary BIfurcation Stent (COBIS) II registry.
국내외구분 국외 SCI여부 SCI
연구책임자역할 공저자
주저자명 Kim MC
교신저자명 Ahn Y
공동저자명 Kim MC, Ahn Y, Sim DS, Hong YJ, Kim JH, Jeong MH, Gwon HC, Kim HS, Rha SW, Yoon JH, Jang Y, Tahk SJ, Seun KB.
게제년월일 2016-10-22
ISSN 1774-024X
Impact Factor 3.285
학술지명 EuroIntervention
서지사항 N집 / N권 / N호,   페이지(N - N)
요약초록문
(Abstract) 입력		 AIMS:
Few data regarding clinical outcomes according to severity of calcification in patients with coronary bifurcation target lesions are available.
METHODS AND RESULTS:
This prospective, multicenter, observational registry enrolled 2,897 patients undergoing percutaneous coronary intervention with drug-eluting stents for coronary bifurcation lesions. We compared target lesion failure (TLF), defined as a composite of cardiac death, non-fatal myocardial infarction (MI), and target lesion revascularization (TLR), according to severity of calcification in coronary bifurcation target lesions, assessed by an angiographic core laboratory using quantitative coronary angiography. Moderate or severe calcification of target bifurcation lesions was observed in 608 (20.9%) patients. During a median follow-up period of 36 months, moderate or severe calcification increased the adjusted risks of TLF (hazard ratio [HR] 1.31, 95% confidence interval [CI]: 1.03-1.68, p=0.031), TLR (HR 1.36, 95% CI: 1.04-1.79, p=0.027), and revascularization (HR 1.39, 95% CI: 1.09-1.78, p=0.009). However, it was not associated with increased risk of cardiac death, MI, or stent thrombosis.
CONCLUSIONS:
Moderate or severe calcification of coronary bifurcation lesions is not uncommon and is associated with unfavorable long-term clinical outcomes, driven mainly by an increased frequency of repeat revascularization.
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