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작성일 : 17-03-17 18:06
논문번호 193
논문제목(영문) Clinical Outcomes according to the Achievement of Target Low Density Lipoprotein-Cholesterol in Patients with Acute Myocardial Infarction.
국내외구분 국내 SCI여부 SCI(E)
연구책임자역할 공저자
주저자명 Ahn T
교신저자명 Suh SY
공동저자명 Ahn T, Suh SY, Lee K, Kang WC, Han SH, Ahn Y, Jeong MH.
게제년월일 2016-05-19
ISSN 1738-5520
Impact Factor 0.706
학술지명 Korean circulation journal.
서지사항 N집 / 47권 / 1호,   페이지(31 - 35)
요약초록문
(Abstract) 입력		 BACKGROUND AND OBJECTIVES:
The clinical outcome of patient with an acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI), with or without achievement of target low density lipoprotein-cholesterol (LDL-C), has little known information. This study investigated if target LDL-C level (below 70 mg/dL) achievements in patients with AMI showed better clinical outcomes or not.
SUBJECTS AND METHODS:
Between May 2008 and September 2012, this study enrolled 13473 AMI patients in a large-scale, prospective, multicenter Korean Myocardial Infarction (KorMI) registry. 12720 patients survived and 6746 patients completed a 1-year clinical follow up. Among them 3315 patients received serial lipid profile follow-ups. Propensity score matching was applied to adjust for differences in clinical baseline and angiographic characteristics, producing a total of 1292 patients (646 target LDL-C achievers vs. 646 non-achievers). The primary end point was the composite of a 1-year major adverse cardiac event (MACE) including cardiac death, recurrent myocardial infarction (MI), target lesion revascularization (TLR) and coronary artery bypass grafting.
RESULTS:
After propensity score matching, baseline clinical and angiographic characteristics were similar between the two groups. Clinical outcomes of the propensity score matched patients who showed no significant differences in cardiac death (0.5% vs. 0.5%, p=1.000), recurrent MI (1.1% vs. 0.8%, p=0.562), TLR (5.0% vs. 4.5%, p=0.649), MACEs (6.5% vs. 5.9%, p=0.644) and stent thrombosis (2.5% vs. 1.9%, p=0.560).
CONCLUSION:
In this propensity-matched comparison, AMI patients undergoing PCI with a target LDL-C (below 70 mg/dL) achievement did not show better clinical outcomes.
파일  C193.Clinical+Outcomes+according+to+the+Achievement+of+Target+Low+Density+Lipoprotein-Cholesterol+in+Patients+with+Acute+Myocardial+Infarction. (1).pdf (119.6K) DATE : 2021-05-26 11:23:13