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논문제목(영문) Thyroid stimulating hormone elevation as a predictor of longterm mortality in patients with acute myocardial infarction
국내외구분 국외 SCI여부 SCI(E)
연구책임자역할 공저자
주저자명 Suk Min Seo
교신저자명 Yoon-Seok Koh
공동저자명 Hun-Jun Park,Dong Bin Kim,Sung Ho Her,Jong Min Lee,Chul Soo Park, Pum-Joon Kim,Young Keun,Myung Ho Jeong Ahn,
게제년월일 2018-08-21
ISSN 0160-9289
Impact Factor 2.248
학술지명 CLINICAL CARDIOLOGY
서지사항 0집 / 41권 / 10호,   페이지(1367 - 1373)
요약초록문
(Abstract) 입력		 Background
Hypothyroidism has been known to be associated with hyperlipidemia, endothelial dysfunction and atherosclerosis. Elevation of thyroid‐stimulation hormone (TSH) is a gold standard to detect these conditions. However, no large studies have investigated the association between TSH elevation and long‐term clinical outcomes in patients with acute myocardial infarction (AMI).

Hypothesis
Hypothyroidism is associated with higher mortality in patients with AMI.

Methods
A total of 4748 AMI patients undergoing percutaneous coronary intervention (PCI) with drug‐eluting stents were consecutively enrolled. We analyzed 1977 patients whose thyroid function data available after the exclusion of hyperthyroidism and possible central hypothyroidism. Patients were divided into two groups; euthyroid group (n = 1846) with normal TSH and normal free thyroxine (FT4); hypothyroidism group (n = 131) with elevated TSH and normal or low FT4. The two groups were subsequently compared with their all‐cause and cardiac mortalities.

Results
Median follow‐up duration was 3.5 years. Hypothyroidism group were older, included in more females, and had higher incidences of atrial fibrillation, stroke, and renal dysfunction. Elevated TSH was associated with significantly higher all‐cause mortality (26.0% vs 11.7%, P < 0.0001) and cardiac mortality (9.2% vs 4.6%, P = 0.014). The multivariate Cox proportional hazards model identified that TSH elevation was a significant predictor of all‐cause mortality (adjusted hazard ratio 1.560, 95% confidence interval 1.017 to 2.392, P = 0.041).

Conclusions
Our data suggest that AMI patients with TSH elevation had worse clinical outcome. Moreover, TSH elevation was a predictor of all‐cause mortality in patients with AMI.

Keywords: acute myocardial infarction, hypothyroidism, thyroid stimulation hormone
파일  C216. Thyroid stimulating hormone elevation as a predictor of long-term mor~.pdf (957.4K) DATE : 2021-05-28 15:16:17