임상

HOME > 연구실적 > 임상 > 논문
 
작성일 : 21-06-03 17:57
논문번호 223
논문제목(영문) Two-year outcomes of statin therapy in patients with acute myocardial infarction with or without dyslipidemia after percutaneous coronary intervention in the era of newgeneration drug-eluting stents within Korean population: Data from the Korea Acute Myo
국내외구분 국외 SCI여부 SCI
연구책임자역할 공저자
주저자명 Yong Hoon Kim
교신저자명 Yong Hoon Kim
공동저자명 Ae-Young Her, Myung Ho Jeong MD,Byeong-Keuk Kim,Dong-Ho Shin,Jung-Sun Kim et at.
게제년월일 2018-12-25
ISSN 1522-1946
Impact Factor 2.044
학술지명 Catheterization and Cardiovascular Interventions
서지사항 0집 / 93권 / 7호,   페이지(1264 - 1275)
요약초록문
(Abstract) 입력		 Background: Limited studies focused on long-term outcomes of statin therapy in patients with acute myocardial infarction (AMI) with or without dyslipidemia after percutaneous coronary intervention (PCI) in the era of new-generation drug-eluting stents (DES). We thought to investigate 2-year clinical outcomes of statin therapy in these patients.

Methods: A total of 18,137 eligible AMI patients (from the Korea AMI Registry [KAMIR]) were finally enrolled and divided into four groups according to the presence or absence of dyslipidemia and statin therapy (dyslipidemia+/statin- [group A, 309 patients], dyslipidemia+/statin+ [group B, 2094 patients], dyslipidemia-/statin- [group C, 672 patients], dyslipidemia-/statin+ [group D, 15062 patients]). The primary outcome was major adverse cardiac event (MACE) defined as all-cause death, myocardial infarction (MI) and revascularization.

Results: During the 2-year follow-up period, the cumulative incidence of MACE in the group A was higher than the group B (adjusted hazard ratio [HR], 2.207; 95% confidence interval (CI), 1.098-3.743; p = .024) and the group D (adjusted HR, 2.110; 95% CI, 1.240-3.593, p = .006). This significantly increased incidence of MACE caused by the higher cumulative incidences of all-cause death and cardiac death (CD) in the group A compared with groups B and D. However, the cumulative incidences of MI and revascularization were not significantly different among these four groups.

Conclusion: Statin therapy demonstrated significantly reduced incidences of MACE, all-cause death and CD compared with non-users after PCI in AMI patients with or without dyslipidemia during 2-year follow-up period in the era of new-generation DES.
파일  C223. Two-year outcomes of statin therapy in patients with acute myocardial_.pdf (1.3M) DATE : 2021-06-03 17:57:20