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논문번호 229
논문제목(영문) Clinical Outcomes at 2 Years Between Beta‑Blockade with ACE Inhibitors or ARBs in Patients with AMI Who Underwent Successful PCI with DES: A Retrospective Analysis of 23,978 Patients in the Korea AMI Registry
국내외구분 국외 SCI여부 SCI
연구책임자역할 공저자
주저자명 Yong Hoon Kim
교신저자명 Yong Hoon Kim
공동저자명 Ae‑Young Her,Myung Ho Jeong,Byeong‑Keuk Kim,Sung‑Jin Hong,Dong‑Ho Shin,Jung‑Sun Kim,Young‑Guk Ko,Donghoon Choi,Myeong‑Ki Hong,Yangsoo Jang
게제년월일 2019-02-20
ISSN 1175-3277
Impact Factor 2.674
학술지명 American Journal of Cardiovascular Drugs
서지사항 0집 / 19권 / 4호,   페이지(403 - 414)
요약초록문
(Abstract) 입력		 Abstract
Introduction Data concerning the clinical impact of combination therapy with β-blockers (BBs)+angiotensin-converting
enzyme inhibitors (ACEIs) compared with BBs+angiotensin-receptor blockers (ARBs) in patients with acute myocardial
infarction (AMI) after percutaneous coronary intervention (PCI) with drug-eluting stents (DES) are limited.
Objective We compared the clinical outcomes at 2 years between these two combination therapies.
Methods We enrolled 23,978 patients with AMI who underwent successful PCI with DES between January 2005 and June
2015 from the Korea AMI Registry (KAMIR) and divided them into the two groups: BB+ACEI (n=17,310) and BB+ARB
(n=6668). The primary endpoint was major adverse cardiac events (MACE), defned as all-cause death, recurrent myocardial
infarction (re-MI), target lesion revascularization (TLR), target vessel revascularization (TVR), and non-TVR. The secondary
endpoints were the cumulative incidences of individual components of MACE and target vessel failure (TVF), a composite
of death related to the target vessel, re-MI, or clinically driven TVR.
Results The relative risk of MACE was higher in the BB+ARB group than in the BB+ACEI group after propensity scorematched
(PSM) analysis (hazard ratio [HR] 1.204; 95% confdence interval [CI] 1.057–1.370; p=0.005). The relative risks
of all-cause death (HR 1.435 [95% CI 1.117–1.845]; p=0.005), cardiac death (HR 1.733 [95% CI 1.253–2.396]; p=0.001),
TVR (HR 1.437 [95% CI 1.157–1.784]; p=0.001), and TVF (HR 1.231 [95% CI 1.065–1.424]; p=0.005) were also higher
in the BB+ARB group after PSM.
Conclusions The BB+ACEI group demonstrated reduced cumulative incidences of MACE, all-cause death, cardiac death,
TVR, and TVF compared with the BB+ARB group in patients with AMI who underwent successful PCI with DES during
a 2-year follow-up period.
파일  C229. Clinical Outcomes at 2 Years Between Beta-Blockade with ACE Inhibitor~.pdf (1.7M) DATE : 2021-06-06 21:55:39