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논문번호 231
논문제목(영문) A comparison of the impact of current smoking on 2-year major clinical outcomes of first- and second-generation drug-eluting stents in acute myocardial infarction
국내외구분 국외 SCI여부 SCI
연구책임자역할 공저자
주저자명 Yong Hoon Kim
교신저자명 Yong Hoon Kim
공동저자명 Ae-Young Her,Myung Ho Jeong,Byeong-Keuk Kim,Sung-Jin Hong,Chul-Min Ahn,Jung-Sun Kim,Young-Guk Ko,Donghoon Choi,Myeong-Ki Hong,Yangsoo Jang
게제년월일 2019-02-14
ISSN 1536-5964
Impact Factor 1.552
학술지명 Medicine
서지사항 0집 / 98권 / 10호,   페이지(e14797 - e14797)
요약초록문
(Abstract) 입력		 Abstract
There are limited studies comparing the effect of current smoking on first-generation (1G)-drug-eluting stents (DES) and secondgeneration
(2G)-DES in acute myocardial infarction (AMI) patients after successful percutaneous coronary intervention (PCI). We
investigated the clinical impact of current smoking on 2-year clinical outcomes between the 1G-DES and the 2G-DES in AMI patients
after PCI.
A total of 11,812 AMI patients with a history of current smoking who underwent successful PCI with 1G-DES (n=4622) or 2G-DES
(n=7190) were enrolled. The primary endpoint was the occurrence of major adverse cardiac events (MACE) defined as all-cause
death, recurrent AMI (re-MI) or any revascularization (target lesion revascularization [TLR], target vessel revascularization [TVR], and
non-TVR). The secondary endpoint was the incidence of definite or probable stent thrombosis (ST).
Two propensity score-matched (PSM) groups (3900 pairs, n=7800, C-statistic=.708) were generated. After PSM analysis, the 2-
year cumulative incidence of MACE was significantly higher in the 1G-DES group compared with the 2G-DES (9.4% vs 7.4%, Logrank
P=.002; hazard ratio, 1.281; 95% confidence interval, 1.097–1.495; P=.002) and this increased incidence of MACE was
associated with the increased incidence of any revascularization including TLR, TVR, and non-TVR. However, the incidences of ST,
all-cause death, re-MI were not significantly different during 2-year follow-up period.
2G-DES was the preferred treatment strategy for AMI patients with a history of current smoking to reduce MACE especially, any
revascularization rate rather than 1G-DES in this study.
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