임상

HOME > 연구실적 > 임상 > 논문
 
작성일 : 21-06-07 16:01
논문번호 234
논문제목(영문) Long-term clinical outcome between beta-blocker with ACEI or ARB in patients with NSTEMI who underwent PCI with drug-eluting stents
국내외구분 국외 SCI여부 SCI
연구책임자역할 공저자
주저자명 Yong Hoon Kim
교신저자명 Yong Hoon Kim
공동저자명 Ae-Young Her, Eun-Seok Shin, Myung Ho Jeong
게제년월일 2019-03-10
ISSN 1671-5411
Impact Factor 2.491
학술지명 Journal of Geriatric Cardiology
서지사항 0집 / 16권 / 3호,   페이지(280 - 290)
요약초록문
(Abstract) 입력		 Abstract
Background Because limited comparative data are available, we decided to compare 2-year major clinical outcomes between
beta-blockers (BB) with angiotensin converting enzyme inhibitors (ACEI) and BB with angiotensin receptor blockers (ARB) therapy in patients
with non-ST-segment elevation myocardial infarction (NSTEMI) after percutaneous coronary intervention (PCI) with drug-eluting
stents (DES). Methods A total 11,288 NSTEMI patients who underwent PCI with DES were enrolled and they were divided into two
groups, the BB with ACEI group (n = 7600) and the BB with ARB group (n = 3688). The major clinical endpoint was the occurrence of
major adverse cardiac events (MACE) defined as all-cause death, recurrent myocardial infarction (re-MI), total revascularization [target lesion
revascularization (TLR), target vessel revascularization (TVR), non-TVR] rate during the 2-year follow-up period. Results After propensity
score-matched (PSM) analysis, two PSM groups (3317 pairs, n = 6634, C-statistic = 0.695) were generated. Although the cumulative
incidences of all-cause death, cardiac death, TLR, and non-TVR were similar between the two groups, MACE (HR = 0.832, 95% CI:
0.7040.982, P = 0.030), total revascularization rate (HR = 0.767, 95% CI: 0.5980.984, P = 0.037), and TVR rate (HR = 0.646, 95% CI:
0.4700.888, P = 0.007) were significantly lower in the BB with ACEI group after PSM. Conclusions In this study, we suggest that the
combination of BB with ACEI may be beneficial for reducing the cumulative incidences of MACE, total revascularization rate, and TVR
rather than the BB with ARB after PCI with DES in NSTEMI patients.
파일  C234. Long-term clinical outcome between beta-blocker with ACEI or ARB in p~.pdf (927.2K) DATE : 2021-06-07 16:01:00