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논문번호 244
논문제목(영문) Efficacy and safety of drug-eluting stents in elderly patients: A meta-analysis of randomized trials.
국내외구분 국외 SCI여부 SCI(E)
연구책임자역할 교신저자
주저자명 Bae S
교신저자명 Jeong MH
공동저자명 Kim Y, Gogas BD, Kim MC, Sim DS, Hong YJ, Kim JH, Ahn Y,
게제년월일 2021-03-01
ISSN 1897-5593
Impact Factor 1.669
학술지명 CARDIOLOGY JOURNAL
서지사항 0집 / 28권 / 2호,   페이지(223 - 234)
요약초록문
(Abstract) 입력		 Background: Current guidelines recommend newer generation drug-eluting stents (DES) over bare-metal stents (BMS) in patients with ischemic heart disease. However, there is no age-specific recommendation in elderly patients.

Methods: Meta-analysis was performed of 6 randomized studies enrolling 5,042 elderly patients who underwent percutaneous coronary intervention (PCI) with stent implantation (DES, n = 2,579; BMS, n = 2,463).

Results: Combined data indicated a significant reduction in major adverse cardiovascular events (MACEs) with use of DES (odds ratio [OR] 0.56, 95% confidence interval [CI] 0.44-0.71, p < 0.001). Moreover, use of DES was associated with a significantly lower incidence of myocardial infarction (OR 0.54, 95% CI 0.36-0.81, p = 0.003) and repeat revascularization (OR 0.44, 95% CI 0.31-0.62, p < 0.001), was compared to that with the use of BMS. Stent thrombosis and bleeding complication rates were not significantly different between groups. In a subgroup meta-analysis, short duration (1 or 6 months) dual antiplatelet therapy (DAPT) was associated with a significantly lower MACE rate (OR 0.49, 95% CI 0.34-0.80; p = 0.003) in elderly patients who underwent PCI with everolimus-eluting stent implantation, compared with that using long duration DAPT.

Conclusions: This meta-analysis provides clinically relevant evidence that DES rather than BMS should be selected for elderly patients.
파일  C244. Efficacy and safety of drug-eluting stents in elderly patients A meta-analysis of randomized trials..pdf (230.9K) DATE : 2021-06-10 09:03:43