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작성일 : 18-05-28 15:25
논문번호 15
논문제목(영문) Successful Coronary Stent Implantation Using Local Nitric Oxide Donor Delivery
국내외구분 국외 SCI여부 SCI(E)
연구책임자역할 주저자
주저자명 Jeong MH
교신저자명 Kang JC
공동저자명 Jeong MH, Ahn YK, Cho JG, Park JC, Na KJ, Kang JC.
게제년월일 2000-05-05
ISSN 1540-8183
Impact Factor 1.88
학술지명 Journal of interventional cardiology
서지사항 0집 / 13권 / 3호,   페이지(191 - 195)
요약초록문
(Abstract) 입력		 With the introduction of high pressure balloon inflations and antiplatelet therapy, the incidence of stent thrombosis has been markedly reduced, but the incidence of late stent restenosis has not. A new strategy may be local drug delivery, which maintains sustained local concentration and limits systemic complications. To evaluate the efficacy of local nitric oxide (NO) donor delivery on stent thrombosis and complications, local NO donor delivery was performed in stented patients. NO donor (2.0‐mg molsidomine) was delivered (1.0 mL/min > 10 min) using the Dispatch Catheter after predilation of target lesions in 13 patients (6 angina, 7 myocardial infarction, age 53.1 ± 11.4 years). After local NO donor delivery, Palmaz‐Schutz stents were placed using standard methods. Follow‐up coronary angiograms were performed 48 hours and 6 months after stenting. None of the patients had hypotensive effects, ischemic symptoms, or ECG changes during and after local NO donor delivery. APTT and CK values were unchanged at 3 and 24 hours after local NO donor delivery and stenting. Follow‐up coronary angiograms at 48 hours and 6 months showed all stents patent with TIMI III flow and without intrastent thrombus. No target lesion revascularization and 100% event‐free survival were observed during the 6‐month clinical follow‐up period. Intracoronary stenting may be performed safely and effectively by local NO donor delivery prior to stent implantation.
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