임상

HOME > 연구실적 > 임상 > 논문
 
작성일 : 21-06-10 11:20
논문번호 270
논문제목(영문) Comparison of First- and Second-Generation Drug-Eluting Stents in Patients with Acute Myocardial Infarction and Prediabetes Based on the Hemoglobin A1c Level
국내외구분 국외 SCI여부 SCI(E)
연구책임자역할 공저자
주저자명 Kim YH, Her AY
교신저자명 Kim YH
공동저자명 Jeong MH, Kim BK, Hong SJ, Kim S, Ahn CM, Kim JS, Ko YG, Choi D, Hong MK, Jang Y
게제년월일 2020-07-18
ISSN 0896-4327
Impact Factor 1.758
학술지명 JOURNAL OF INTERVENTIONAL CARDIOLOGY
서지사항 0집 / 2020권 / 1710439호,   페이지(1 - 11)
요약초록문
(Abstract) 입력		 Objective. To compare major clinical outcomes after successful percutaneous coronary intervention (PCI) with first-generation (1G) drug-eluting stents (DES) and second-generation (2G) DES in patients with acute myocardial infarction (AMI) and prediabetes.Background. Patients with prediabetes are associated with an increased incidence of coronary artery disease. The relative superiority of 1G- and 2G-DES in these patients is not well established.Methods. A total of 4997 patients with AMI and prediabetes were divided into two groups: the 1D-DES group (n = 726) and the 2G-DES group (n = 4271). The primary outcomes were the patient-oriented composite outcomes (POCOs) defined as all-cause death, recurrent myocardial infarction (Re-MI), and any disease revascularization at 2-year follow-up. The secondary outcome was probable or definite stent thrombosis (ST).Results. After propensity score-matching (PSM) analysis, two PSM groups (698 pairs,n = 1396, C-statistics = 0.725) were generated. The cumulative incidence rates of POCOs (hazard ratio (HR): 1.467; 95% confidence interval (CI): 1.068-2.015;p=0.018), any disease revascularization (HR: 2.259; 95% CI: 1.397-3.654;p=0.001), and ST (HR: 4.361; 95% CI: 1.243-15.30;p=0.021) in the 1G-DES group were significantly higher than those in the 2G-DES group. However, the cumulative incidence rates of all-cause death, cardiac death, and Re-MI were similar between the two groups.Conclusions. In patients with AMI and prediabetes, 2G-DES implantation was more efficacious than 1G-DES implantation over a 2-year follow-up period. However, further studies are needed to confirm these results.
파일  C270. Comparison of First- and Second-Generation Drug-Eluting Stents in Patie~.pdf (2.2M) DATE : 2021-06-10 11:20:57