논문번호 | 100 | ||
논문제목(영문) | Fabrication and Evaluation of Polyelectrolyte Complexes of Dextran Derivatives for Drug Coating of Coronary Stents | ||
국내외구분 | 국내 | SCI여부 | KCI |
연구책임자역할 | 교신저자 | ||
주저자명 | Eun-Jae Jang | ||
교신저자명 | Myung Ho Jeong | ||
공동저자명 | Eun-Jae Jang, So-Youn Lee, In-Ho Bae, Dae Sung Park, Myung Ho Jeong, Jun-Kyu Park | ||
게제년월일 | 2019-08-20 | ||
ISSN | 1225-0112 | ||
Impact Factor | 4.978 | ||
학술지명 | Applied Chemistry for Engineering | ||
서지사항 | 0집 / 30권 / 5호, 페이지(586 - 590) | ||
요약초록문 (Abstract) 입력 |
The aim of this study was to fabricate a dextran polyelectrolyte multi-layer on a bare metal stent (BMS) and to evaluate bio-physical properties of the layer. Diethylaminoethyl-dextran (DEAE-D) as a polycation and dextran sulfate (DS) as a polyanion were successively coated on the bare metal stent by a well-known layer-by-layer procedure. The morphology of the stent surface and its cell adhesion were studied after each coating step by scanning electron microscopy. The stent showed more blotched and slightly rougher morphology after dextran-DS coating. The contact angle of the DEAE-DS group (39.5 ± 0.15°) was significantly higher than that of the BMS group (45.16 ± 0.08°), indicating the improvement of hydrophilic. The SMC proliferation inhibition in the DEAE-DS-coated stent group (20.9 ± 0.04%) was stronger than that in the control group (21.7 ± 0.10% in DS-coated group only). The DEAE-DS coating is desired for stent coating materials with biocompatibility and anti-restenosis effect. |
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