논문번호 | 104 | ||
논문제목(영문) | Mechanical and physio-biological properties of peptide-coated stent for reendothelialization | ||
국내외구분 | 국내 | SCI여부 | SCI |
연구책임자역할 | 교신저자 | ||
주저자명 | In-Ho Bae | ||
교신저자명 | Myung Ho Jeong | ||
공동저자명 | In-Ho Bae, Myung Ho Jeong, Dae Sung Park, Kyung Seob Lim, Jae Won Shim, Mun Ki Kim & Jun-Kyu Park | ||
게제년월일 | 2020-01-23 | ||
ISSN | 2055-7124 | ||
Impact Factor | 4.385 | ||
학술지명 | Biomaterials Research | ||
서지사항 | 0집 / 24권 / 4호, 페이지(0 - 0) | ||
요약초록문 (Abstract) 입력 |
Background: The aim of this study was to characterize the mechanical and physio-biological properties of peptidecoated stent (PCS) compared to commercialized drug-eluting stents (DESs). Methods: WKYMVm (Trp-Lys-Tyr-Met-Val-D-Met), a stimulating peptide for homing endothelial colony-forming cell was specially synthesized and coated to bare metal stent (BMS) by dopamine-derived coordinated bond. Biological effects of PCS were investigated by endothelial cell proliferation assay and pre-clinical animal study. And mechanical properties were examined by various experiment. Results: The peptide was well-coated to BMS and was maintained and delivered to 21 and 7 days in vitro and in vivo, respectively. Moreover, the proliferation of endothelial cell in PCS group was increased (approximately 36.4 ± 5.77%) in PCS group at 7 day of culture compare to BMS. Although, the radial force of PCS was moderated among study group. The flexibility of PCS was (0.49 ± 0.082 N) was greatest among study group. PCS did not show the outstanding performance in recoil and foreshortening test (3.1 ± 0.22% and 2.1 ± 0.06%, respectively), which was the reasonable result under the guide line of FDA (less than 7.0%). The nominal pressure (3.0 mm in a diameter) of PCS established by compliance analysis was 9 atm. The changing of PCS diameter by expansion was similar to other DESs, which is less than 10 atm of pressure for the nominal pressure. Conclusions: These results suggest that the PCS is not inferior to commercialized DES. In addition, since the PCS was fabricated as polymer–free process, secondary coating with polymer-based immunosuppressive drugs such as –limus derivatives may possible. |
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