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논문번호 44
논문제목(영문) Thromboresistant and endothelialization effects of dopamine-mediated heparin coating on a stent material surface.
국내외구분 국외 SCI여부 SCI(E)
연구책임자역할 교신저자
주저자명 Bae IH
교신저자명 Jeong MH
공동저자명 Bae IH, Park IK, Park DS, Lee H, Jeong MH;
게제년월일 2012-02-13
ISSN 1573-4838
Impact Factor 2.587
학술지명 Journal of materials science. Materials in medicine
서지사항 0집 / 23권 / 5호,   페이지(1259 - 1269)
요약초록문
(Abstract) 입력		 Heparinization of surfaces has proven a successful strategy to prevent thrombus formation. Inspired by the composition of adhesive proteins in mussels, the authors used dopamine to immobilize heparin on a stent surface. This study aimed to assess the thromboresistant and endothelialization effects of dopamine-mediated heparin (HPM) coating on a stent material surface. The HPM was synthesized by bonding dopamine and heparin chemically. Cobalt-chromium (Co-Cr) alloy disks were first placed in the HPM solution and applied to surface stability then underwent thromboresistant tests and human umbilical vein endothelial cells (HUVEC) cytotoxicity assays. The results showed not only thromboresistant activity and a stable state of heparin on the surfaces after investigation with toluidine blue and thrombin activation assay but also proliferation of HUVEC in vitro. Studies on animals showed that the HPM-coated stent has no obvious inflammation response and increasing of restenosis rate compared to the bare metal stent (BMS) indicating good biocompatibility as well as safety in its in vivo application. Moreover, improving the endothelial cell (EC) proliferation resulted in a higher strut-covering rate (i.e., endothelialization) with shuttle-shaped EC in the HPM-coated stent group compared to that of the BMS group. These results suggest that this facile coating approach could significantly promote endothelialization and offer greater safety than the BMS for its much improved thromboresistant property. Moreover, it may offer a platform for conjugating secondary drugs such as anti-proliferative drugs.
파일  B44. J Mater Sci Mater Med. 2012;23(5)1259-1269..pdf (650.0K) DATE : 2016-03-13 09:27:15