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논문번호 15
논문제목(영문) The Inhibitory Effects of Platelet Glycoprotein IIb/IIIa Receptor Blocker-Coated Stent on Neointima Formation and Inflammatory Response in Porcine Coronary Stent Restenosis.
국내외구분 국내 SCI여부 SCI(E)
연구책임자역할 교신저자
주저자명 Park OY
교신저자명 Jeong MH
공동저자명 Park OY, Jeong MH, Kim JH, Kim W, Lee SH, Hong YJ, Kim JH, Park WS, KimI S, Choi MJ, AhnY, Park JT, Cho JG, ChoDL, Park JC, Kang JC;
게제년월일 2003-03-22
ISSN 1738-5520
Impact Factor 0.753
학술지명 Korean Circulation J
서지사항 0집 / 33권 / 5호,   페이지(439 - 445)
요약초록문
(Abstract) 입력		 Background and Objectives：Previously, we reported that Abciximab (ReoPro®)-coated stent inhibited in-stent neointimal hyperplasia. ReoPro® is known to suppress vascular inflammation through CD 11b/18 (macrophage-1 receptor). We observed inhibitory effects of neointima formation and inflammatory reaction after stenting in a porcine model.
Materials and Methods：The surface of the stent was coated with ReoPro® by means of plasma polymerization followed by chemical grafting. Stent overdilation injury was performed with control bare stent (Group I, n=13) and ReoPro®-coated stents (Group II, n=13) in 26 porcine coronary arteries. Follow-up coronary angiogram and the histopathologic assessments of stented porcine coronary were performed on day 14 (Group I：n=6, Group II：n=6) and day 28 (Group I：n=7, Group II：n=7) after stenting.
Results：Pathologic area stenosis was 19.7±5.3% in Group I and 15.9±3.3% in Group II at day 14, and 33.6±27.7% and 22.6±6.6%, respectively, at day 28 (p<0.05 at day 28). The ratio of inflammatory cells out of the number of total cells in the neointima was 21.8±6.5% in Group I and 22.5±11.6% in Group II at day 14, and 27.3±18.3% in Group I and 28.6±10.7% in Group II at day 28 post stenting (p=NS). And those of the media were 2.89±1.13% in Group I and 1.36±1.27% in Group II at day 14, and 6.61±5.61% and 6.26±4.51% at day 28 (p=NS). Fibrinoid materials associated with inflammatory reaction were observed in both groups at days 14 and 28.
Conclusion：An inflammatory reaction was not suppressed with the use of ReoPro®-coated stenting in a porcine stent restenosis model.
파일  B15. Korean Circulation J 2003;33(5)439-445..pdf (2.1M) DATE : 2016-03-13 07:18:24