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논문번호 16
논문제목(영문) The Effect of the Probucol-Loaded BiodivYsioTM DD Stent on Inhibition of Neointimal Proliferation in Porcine Coronary Stent Restenosis Model.
국내외구분 국내 SCI여부 SCI(E)
연구책임자역할 교신저자
주저자명 Kim W
교신저자명 Jeong MH
공동저자명 Kim W, Jeong MH, Cha KS, Lee SH, Lim JH, Kim HG, Park HW, Hong YJ, Park OY, Kim JH, Ahn Y, Park JT, Kim MH, Cho JG, Park JC, Kang JC;
게제년월일 2003-07-31
ISSN 1738-5520
Impact Factor 0.753
학술지명 Korean Circulation J
서지사항 0집 / 33권 / 11호,   페이지(1028 - 1035)
요약초록문
(Abstract) 입력		 Background and Objectives：In a recent multicenter trial probucol was found to reduce stent restenosis by improving the lumen dimension. The probucol was administered for 2 weeks before, and 4 weeks after, stenting. The release of the drug at the site of a vascular injury, via polymer-coated stents, helps achieve an effective local concentration. The feasibility of a probucol stent coating in reducing in-stent restenosis was assessed. Materials and Methods：The probucol loading and in vitro release were assessed using BiodivYsioTM stents, in a 50 mg/mL probucol solution. After being dip-coated with probucol (n=8), or a control (n=8) solution, the stents were implanted in 8 pigs. Angiography and histopathological analyses were performed 28 days later. Results：The total probucol loading was 52±16 μg/stent, with no release for up to 72 hours after loading. No pig died until sacrifice. On angiography, the reference and minimum lumen diameters showed no significant differences between the two groups, with similar diameters stenosis (8.7±3.68 vs. 13.3±4.18%, p=0.120). On histomorphometry, the injury scores, vessel, lumen and neointimal areas showed no significant differences between the groups, with similar areas of stenosis (23.1±12.39 vs. 25.2±8.22%, p=0.671). The degrees of re-endothelialization, inflammation and smooth muscle cell proliferation were not significantly different. Conclusion：Probucol can be loaded onto a polymercoated stent, and does not release from the stent for up to 72 hours after loading. About 52 μg probucol per stent does not reduce in-stent restenosis in porcine coronary arteries.
파일  B16. Korean Circulation J 2003;33(11)1028-1035..pdf (1.2M) DATE : 2016-03-13 07:20:23