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논문번호 20
논문제목(영문) Effect of anti-oxidant (carvedilol and probucol) loaded stents in a porcine coronary restenosis model.
국내외구분 국외 SCI여부 SCI(E)
연구책임자역할 교신저자
주저자명 Kim W
교신저자명 Jeong MH
공동저자명 Kim W, Jeong MH, Cha KS, Hyun DW, Hur SH, Kim KB, Hong YJ, Park HW, Kim JH, Ahn YK, Kim MH, Cho JG, Park JT, Park JC, Kang JC;
게제년월일 2004-10-07
ISSN 1346-9843
Impact Factor 3.940
학술지명 Circulation journal
서지사항 0집 / 69권 / 1호,   페이지(101 - 106)
요약초록문
(Abstract) 입력		 BACKGROUND:
The long-term clinical efficacy of intracoronary stenting is limited by restenosis and delivery by the stent of agents inhibiting cell cycle progression should prevent in-stent neointimal hyperplasia. Carvedilol is an antioxidant that inhibits smooth muscle cell proliferation and migration, whereas probucol is a vascular protectant and reduces stent restenosis by improving the lumen dimension at the stent placement site.
METHODS AND RESULTS:
BiodivYsio phosphorylcholine-coated stents were dip-coated with carvedilol (5 mg/ml) or probucol (50 mg/ml) by immersion in respective methanol solutions. Twenty-four stents (carvedilol=8, probucol=8, control=8) were placed in 12 pigs and histopathologic analysis was done 4 weeks later. Histomorphometry of the carvedilol-coated stent group compared with the control groups showed that the neointimal area decreased by 42% (1.12+/-0.55 mm2 in the carvedilol group vs 1.92+/-0.52 mm2 in the control, p=0.004) and the lumen area increased by 20% (5.15+/-0.90 mm2 vs 4.17+/-0.87 mm2, p=0.008), resulting in a 43% reduction of the percent area stenosis (18.22+/-9.6% vs 31.9+/-9.2%, p=0.002). In the probucol-coated stent group, the lumen area, neointimal area, and %area stenosis did not different significantly from the control group. There were 7.7+/-2.97% proliferating nuclear cell antigen-positive cells in the carvedilol-coated stent group compared with 17.8+/-1.45% in the control group (p=0.0001) and 15.9+/-1.91% in the probucol group (vs control, p=NS).
CONCLUSIONS:
The carvedilol-coated stent, but not the probucol-coated one, inhibited neointimal hyperplasia in a porcine stent restenosis model.
파일  B20. Circ J. 2005;69(1)101-106..pdf (287.5K) DATE : 2016-03-13 07:30:48