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논문번호 31
논문제목(영문) Experience with Endothelial Progenitor Cell Capturing Aptamers for Coating of Intracoronary Stents in a Porcine Model.
국내외구분 국내 SCI여부 SCI(E)
연구책임자역할 공저자
주저자명 Sim DS
교신저자명 Ahn Y
공동저자명 Sim DS, Kown JS, Kim YS, Chung HC, Hong YJ, Park HW, Kim JH, Jeong MH, Cho JG, Park JC, Kang JC, Han BS, Ahn Y;
게제년월일 2009-03-15
ISSN Tissue Engineering and Regenerative Medicine
Impact Factor 1.088
학술지명 Tissue Eng Regen Med 2009;(6)555-561.
서지사항 0집 / 6권 / 4호,   페이지(555 - 561)
요약초록문
(Abstract) 입력		 Aptamers, capture molecules(oligonucleotides) for endothelial progenitor cells(EPCs), are able to recognize circulating EPCs and to bind them. To evaluate effects of the aptamer-coated stent, six pigs were utilized and three different stents-cobalt-chromium bare-metal stent(CC), paclitaxel-eluting Taxus stent(Boston Scientific, Natick, Massachusetts)(TA), and aminoparylene and aptamer-coated stent (AA)-were implanted in the three epicardial coronary arteries in a random fashion at 8 to 10 atm. Stent length and diameter was 18 mm and 3 mm. After one month, the animals underwent follow-up coronary angiography with acetylcholine(10 mL, 3 ug/mL) stimulation test and were euthanized for histologic analysis. There was a decrease in MLD in all stents: CC(12.3 ± 5.5%), TA(10.4 ± 3.7%), and AA(11.2 ± 6.3%). There was, however, no statistical difference between the groups. Neointimal
thickness was lower in TA. During the acetylcholine stimulation test, severe spasm (total occlusion) was noted in 1 pig at the proximal and distal edges of the Taxus stent. Re-endothelialization score was 3.40 ± 0.52, 1.33 ± 0.52, and 3.60 ± 0.55 in CC, TA, and AA, respectively. Thrombus appearance rate was 0/6, 4/6, and 1/6 in CC, TA, and AA, respectively. The AA showed a tendency toward lower incidence of stent thrombosis and endothelial dysfunction than TA. However, the inhibition of neointimal hyperplasia was not different between CC and AA.
파일  B31. Tissue Eng Regen Med 2009;6(4)555-561..pdf (5.9M) DATE : 2016-03-13 08:37:30