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논문번호 37
논문제목(영문) Comparison of bare metal stent and paclitaxel-eluting stent using a novel rat aorta stent model.
국내외구분 국외 SCI여부 SCI(E)
연구책임자역할 공저자
주저자명 Kwon JS
교신저자명 Ahn Y, Kim DW
공동저자명 Kwon JS, Park RK, Shim TJ, Jeong MH, Cho MC, Ahn Y, Kim DW;
게제년월일 2010-08-17
ISSN 1229-845X
Impact Factor 1.164
학술지명 Journal of veterinary science
서지사항 0집 / 12권 / 2호,   페이지(143 - 149)
요약초록문
(Abstract) 입력		 The purpose of our study was to create a novel rat aorta stent implantation model. Stainless steel bare metal stents (BMS) or paclitaxel-eluting stents (PES) were implanted in male Sprague-Dawley rats (BW 400 ± 20 g). Two and four weeks after stent implantation, the aorta were collected, fixed with 2% glutaraldehyde, and cut into two segments. One segment was used for scanning electron microscopy analysis to evaluate re-endothelialization, and the other segment was used to calculate the neointimal area. At 2 weeks after stenting, the appearance of neointimal hyperplasia was less in the PES group than in the BMS group. At 4 weeks after stenting, no significant difference in neointimal hyperplasia was observed between two groups. On the other hand, the PES group showed more thrombus formation and less re-endothelialization compared to the BMS group. This study demonstrated the ability of a novel rat model of aorta stenting via a common carotid artery to measure the efficacy and safety of commercially available drug-eluting stents.
파일  B37. J Vet Sci. 2011;12(2)143-149..pdf (3.6M) DATE : 2016-03-13 09:02:38