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논문번호 43
논문제목(영문) A Reliable porcine coronary model of chronic total occlusion using copper wirestents and bioabsorbable levo-polylactic acid polymer.
국내외구분 국외 SCI여부 SCI(E)
연구책임자역할 교신저자
주저자명 Sim DS
교신저자명 Jeong MH
공동저자명 Sim DS, Jeong MH, Cha KR, Park SH, Park JO, Shin YM, Shin H, Hong YJ, Ahn Y,Schwartz RS, Kang JC.;
게제년월일 2012-07-06
ISSN 0914-5087
Impact Factor 2.782
학술지명 Journal of Cardiology
서지사항 0집 / 60권 / 6호,   페이지(443 - 447)
요약초록문
(Abstract) 입력		 BACKGROUND: Chronic total occlusion (CTO) remains a challenge in interventionalcardiology. We investigated the feasibility and reliability of copper wire stents and levo-polylactic acid (l-PLA) as a means of CTO induction in a porcine model.
METHODS AND RESULTS: In one group of 20 swine, copper stents were crimped on a 3.0mm angioplasty balloon and inserted into the mid-left anterior descending coronary artery (LAD). In the other group of 20 swine, l-PLA was wrapped on a guidewire and pushed into the distal LAD with a 3.0mm balloon catheter to induce embolization. Of 20 swine which underwent copper stent implantation, 13 died ofstent thrombosis. In the remaining 7 swine, total or near total occlusion with collateral circulation was observed at 5 weeks. Of 20 swine which underwent l-PLAembolization, 4 died of ventricular fibrillation during or shortly after the procedure. Serial histopathologic studies showed complete absorption of the polymer with replacement by fibrotic tissue approximately 4 weeks following the polymer implantation.
CONCLUSIONS: CTO could be reliably induced in porcine coronary arteries by copperstents and l-PLA. These models may support investigation of new percutaneous devices to facilitate CTO interventions.
파일  B43. J Cardiol. 2012;60(6)443-447..pdf (997.3K) DATE : 2016-03-13 09:24:40