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논문번호 48
논문제목(영문) New drug-eluting stents to prevent stent thrombosis and restenosis for acute myocardial infarction: from the experience of Korean acute myocardial infarction registry.
국내외구분 국내 SCI여부 KCI
연구책임자역할 교신저자
주저자명 Bae IH
교신저자명 Jeong MH
공동저자명 Bae IH, Jeong MH;
게제년월일 2012-10-24
ISSN 0277-786X
Impact Factor 0
학술지명 Nanosystems in Engineering and Medicine
서지사항 0집 / 8548권 / 3호,   페이지(1 - 7)
요약초록문
(Abstract) 입력		 Drug-eluting stents (DES) are superior to bare metal stents (BMS) in reducing restenosis rates across a wide range of patients and lesion subsets. This study presented the investigation of one-year clinical follow-up were registered in 52 primary percutaneous coronary intervention sites in Korea, and pre-clinical results of various drug-coated stent fabricating with many other coating approaches on physiological parameters, Based on our clinical study adverse cardiac events were 17.4 % after DES implantation, which was significantly lower compared with 24.9% of BMS implanted patients. As assumption above outcome, it well repays research and development in new DES. Our research group carefully chooses abciximab, alpha-lipoic acid, heparin / dopamine, inhibitors in cell signal cascade were employed as coating drug. These drug candidates were coated on BMS surface by various methods such as TiO2 film deposited by plasma enhanced chemical vapor deposition, ultrasonic sprayer / simple-dip coating, or bio-inspired natural binding technique. In vitro and in vivo results of these new DES fabricated by our research group have showed superior outcomes compare to BMS on physiological parameters such as inflammation score, re-endothelialization, preventing neointema or thrombosis etc. These results are promising safer and more effective to overcome the limitation of DES. © (2012) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
파일  B48. SPIE 2012;8548(3)1-7..pdf (178.0K) DATE : 2016-03-13 10:07:27