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논문번호 53
논문제목(영문) Histopathological Analysis of Drug-Eluting Stents in a Porcine Coronary Restenosis Model.
국내외구분 국내 SCI여부 KCI
연구책임자역할 교신저자
주저자명 Lim KS
교신저자명 Jeong MH
공동저자명 Lim KS, Bae IH, Park DS, Kim JM, Jeong MH;
게제년월일 2015-05-09
ISSN 2055-7124
Impact Factor 0
학술지명 Biomaterials Research
서지사항 0집 / 17권 / 2호,   페이지(62 - 66)
요약초록문
(Abstract) 입력		 The aim of this study was to compare the two types of drug-eluting stents with histological analysis in porcine coronary restenosis model. Pigs were randomized into two groups in which the coronary arteries (12 pigs, 12 coronaries in each group) had either biolimus-eluting stent with biodegradable polymer (BPS) or sirolimus-eluting stent with durable polymer (DPS). Radiological analysis was performed pre-stent and post-stent implantation and histopathologic analysis was assessed at 28 days after stenting. Angiographic finding showed that the coronary artery was more narrowed by neointima proliferation in BPS compared to DPS. In histopathological analysis, the internal elastic lamina (IEL), lumen area, neointima area, percent area stenosis, and fibrin score were significantly different between the two groups (5.1 ± 0.79 mm2, 2.8 ± 0.85 mm2, 2.3 ± 0.75 mm2, 45.9 ± 13.43%, 0.4 ± 0.79 in BPS group vs. 4.2 ± 0.93 mm2, 3.0 ± 0.90 mm2, 1.2 ± 0.67 mm2, 28.1 ± 14.81%, 2.0 ± 0.93 in DPS group, respectively). However, there was no significant difference in injury and inflammation score (1.3 ± 0.40, 1.0 ± 0.31 in BPS group vs. 1.3 ± 0.32, 1.1 ± 0.15 in DPS group, respectively). Our study demonstrated that BPS was not effective to reduce neointima hyperplasia at 1 month after implantation of stents in porcine coronary artery. However, fibrin score of BPS which means delayed arterial healing is very lower than that of DPS.
파일  B53. Biomaterials Research. 2013;17(2)62-66..pdf (1.8M) DATE : 2016-03-13 10:20:14