비임상

HOME > 연구실적 > 비임상 > 논문
 
작성일 : 16-03-13 06:47
논문번호 8
논문제목(영문) The effects of local delivery of paclitaxel nanoparticle on porcine coronary stent restenosis.
국내외구분 국내 SCI여부 SCI(E)
연구책임자역할 교신저자
주저자명 Cha KS
교신저자명 Jeong MH
공동저자명 Cha KS, Jeong MH, Lee SU, Cho CS, Joo SB, Kim NH, Kim KH, Cho JH, Kim SH, Ahn Y, Cho JG, Lee JH, Park CS, Park JC, Kang JC;
게제년월일 1999-12-22
ISSN 1738-5520
Impact Factor 0.753
학술지명 Korean Circulation J
서지사항 0집 / 30권 / 2호,   페이지(208 - 220)
요약초록문
(Abstract) 입력		 Background and Objectives：Late coronary in-stent restenosis remains an important clinical problem in coronary intervention. The effects of Paclitaxel (Taxol), an antimicrotubule agent, on neointimal proliferation within porcine coronary arteries were evaluated.
Method：Stent overdilation injury was performed in porcine coronary arteries without local delivery of paclitaxel (n＝10, Group Ⅰ). Stent overdilation injury was also performed after local delivery of paclitaxel nanoparticle using the Dispatch Catheter TM in other coronary arteries (n＝10, Group Ⅱ). Coronary angiography and histopathologic examinations, which were performed 4 weeks after stenting, and complete blood counts and blood chemistry before and 4 weeks after the local delivery were compared.
Result：1) Reference vessel diameter, stented artery diameter, and diameter stenosis were not different between two groups. 2) Histopathologic injury score, external elastic lamina area, internal elastic lamina area, and luminal area were not different between two groups. 3) Neointimal area and histopathologic area stenosis were smaller significantly in the group Ⅱthan in group Ⅰ (2.3±0.33 vs 3.7±1.40 mm2, 22.2±19.26 vs 31.1±7.15%；p＝0.04, 0.03, respectively). 3) Proliferating cell nuclear antigen index was lower in the stent overdilation injury with local paclitaxel delivery group than in the stent overdilation injury alone (31.10±3.70 vs 46.80±5.20%, p＝0.04). 4) No significant laboratory changes were observed before and 4 weeks after the local delivery.
Conclusion：Local delivery of paclitaxel nanoparticle inhibits neointima formation after stent overdilation injury in porcine coronary arteries without systemic toxicity.
파일  B8.+Korean+Circulation+J+2000;30(2)208-220..pdf (5.0M) DATE : 2021-05-21 10:34:06