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논문번호 57
논문제목(영문) Effect of polymer-free TiO2 stent coated with abciximab or alpha lipoic acid in porcine coronary restenosis model.
국내외구분 국외 SCI여부 SCI(E)
연구책임자역할 교신저자
주저자명 Lim KS
교신저자명 Jeong MH
공동저자명 Lim KS, Jeong MH, Bae IH, Park JK, Park DS, Kim JM, Kim JH, Kim HS, Kim YS, Jeong HY, Song SJ, Yang EJ, Cho DL, Sim DS, Park KH, Hong YJ, Ahn Y;
게제년월일 2014-02-06
ISSN 0914-5087
Impact Factor 2.782
학술지명 Journal of cardiology
서지사항 0집 / 64권 / 5호,   페이지(409 - 418)
요약초록문
(Abstract) 입력		 BACKGROUND:
Polymer-free drug-eluting stents (DES) may overcome the shortcomings of polymer-based DES. The aim of this study was to examine the effect of the polymer-free TiO2 film-coated stent with abciximab or alpha lipoic acid in a porcine coronary overstretch restenosis model.
METHODS:
Pigs were randomized into four groups in which the coronary arteries (24 pigs, 48 coronaries in each group) had TiO2 film-coated stent with abciximab (TCA, n = 12), TiO2 film-coated stent with alpha lipoic acid (TCALA, n = 12), biolimus A9-eluting stents with biodegradable polymer (BES, n = 12), and TiO2 film-coated stent (TCstent, n = 12). Histopathologic analysis was performed at 28 days after stenting.
RESULTS:
There was no significant difference in the injury score and internal elastic lamina (IEL) among the four groups. There were significant differences in the lumen area, neointima area, percent area stenosis, fibrin score, and inflammation score among the four groups [2.7 ± 1.0mm(2), 2.6 ± 0.94 mm(2), 48.9 ± 16.25%, 1.0 (range 0.0-3.0), 1.0 (range 0.0-2.0) in TCA stent group vs. 2.7 ± 1.24 mm(2), 2.9 ± 0.83 mm(2), 53.5 ± 17.19%, 1.0 (range 0.0-2.0), 1.0 (range 0.0-2.0) in TCALA stent group vs. 2.7 ± 1.30 mm(2), 2.6 ± 1.06 mm(2), 50.1 ± 23.20%, 2.0 (range 1.0-3.0), 2.0 (range 1.0-3.0) in BES group vs. 1.7 ± 0.63 mm(2), 3.3 ± 0.58 mm(2), 60.2 ± 10.12%, 0.5 (range 0.0-2.0), 1.0 (range 0.0-2.0) in TC stent group, respectively].
CONCLUSION:
TCA and TCALA are more effective to reduce neointimal hyperplasia compared to TC. Moreover, fibrin and inflammation scores are significantly lower in TCA and TCALA than BES in porcine coronary restenosis model.
파일  B57. J Cardiol. 2014;64(5)409-418..pdf (5.5M) DATE : 2016-03-13 10:29:25