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작성일 : 16-03-13 10:31
논문번호 58
논문제목(영문) Comparison of Sirolimus Loaded PLGA-PEG Co-polymer Coronary Stent and Bare Metal Stent in Porcine Coronary Restenosis Model.
국내외구분 국내 SCI여부 SCI(E)
연구책임자역할 교신저자
주저자명 Lim KS, Park JK
교신저자명 Jeong MH
공동저자명 Lim KS, Park JK, Jeong MH, Nah JW, Kim DG, Bae IH, Park DS, Kim JM, Kim JH, Cho DL, Sim DS, Park KH, Hong YJ, Ahn Y;
게제년월일 2014-06-01
ISSN 1598-5032
Impact Factor 1.682
학술지명 Macromolecular Research
서지사항 0집 / 22권 / 6호,   페이지(639 - 646)
요약초록문
(Abstract) 입력		 The aim of this study was to compare the effect of the sirolimus loaded PLGA-PEG co-polymer coronary stent with that of the bare metal stent in a porcine coronary restenosis model. Pigs were randomized into two groups (10 pigs, 10 coronary arteries in each group), in which either the sirolimus loaded PLGA-PEG copolymer stent (SPPS, n=10) or the bare metal stent (BMS, n=10) was implanted in the coronary arteries. Histopathologic analysis was performed at 28 days after stenting. There were no significant differences in the injury score, internal elastic lamina (IEL) area, and inflammation score between the two groups. There were significant differences in the lumen area (3.6±0.42 mm2 in the SPPS group vs. 2.5±0.89 mm2 in the BMS group, p<0.001), in the neointimal area (1.2±0.34 mm2 in the SPPS group vs. 2.5±0.99 mm2 in the BMS group, p<0.001), in the percent area stenosis (26.0±6.58% in the SPPS group vs. 48.6±16.95% in the BMS group, p<0.001) and in the fibrin score (1.2±0.41 in the SPPS group vs. 0.5±0.26 in the BMS group, p<0.001). These results demonstrate that SPPS had a superior effect on suppression of neointimal hyperplasia than BMS at one month after stenting in a porcine coronary restenosis model.
파일  B58. Macromol Res. 2014;22(6)639-646..pdf (1.1M) DATE : 2016-03-13 10:31:14