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논문번호 69
논문제목(영문) Development of a novel drug-eluting stent consisting of an abluminal and luminal coating layer dual therapy system.
국내외구분 국외 SCI여부 SCI(E)
연구책임자역할 공저자
주저자명 Park JK
교신저자명 Park CH
공동저자명 Park JK, Lee JH, Nah JW, Kim HK, Lim KS, Bae IH, Jeong MH, Unnuthan AR, Kim CS, Park CH;
게제년월일 2015-04-20
ISSN 2046-2069
Impact Factor 3.840
학술지명 RSC ADVANCES
서지사항 0집 / 5권 / 1호,   페이지(40700 - 40707)
요약초록문
(Abstract) 입력		 The aim of this study was to develop a dual drug-coated stent using a bi-directional coating system. Sirolimus (SRL) was coated onto the abluminal area of the stent to prevent restenosis, and WKYMVm, a peptide for endothelial homing, was coated onto the luminal area of the stent to enhance endothelialization. To verify the bidirectional coating of materials, various morphological analysis was carried out by using optical microscopy, scanning electron microscopy, and fluorescence microscopy. The release velocities of the drugs coated onto the luminal and abluminal surfaces of the stent were investigated by using instruments that mimic the body’s circulation system. The proliferation of smooth muscle cells was inhibited by SRL, whereas the proliferation of human umbilical vein endothelial cells was enhanced by WKYMVm. This study demonstrated that it is feasible to separate coating layers of the stent strut with new coating technology for the bi-directional function of drugs.
파일  B69.+RSC+Adv.+2015;5(1)40700-40707..pdf (2.6M) DATE : 2021-05-21 11:21:47